Spinogenesis and Pruning in the Anterior Ventral Inferotemporal Cortex of the Macaque Monkey: An Intracellular Injection Study of Layer III Pyramidal Cells

Elston, Guy N.; Oga, Tomofumi; Okamoto, Tsuguhisa; Fujita, Ichiro

doi:10.3389/fnana.2011.00042

Cited by 39 publications

(38 citation statements)

References 184 publications

(230 reference statements)

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“…The cell-body area and total dendritic length were also calculated from these 2-dimensional projections for compatibility with previous studies (see Figure 3B, inset) (e.g., Elston et al, 1996, 2009, 2010a,b, 2011b; Elston and Rosa, 1997, 1998). The branching profiles of dendritic trees were determined by Sholl analysis (Sholl, 1953).…”

Section: Methodsmentioning

confidence: 85%

Postnatal Dendritic Growth and Spinogenesis of Layer-V Pyramidal Cells Differ between Visual, Inferotemporal, and Prefrontal Cortex of the Macaque Monkey

Oga

Elston²,

Fujita

2017

Front. Neurosci.

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Pyramidal cells in the primate cerebral cortex, particularly those in layer III, exhibit regional variation in both the time course and magnitude of postnatal growth and pruning of dendrites and spines. Less is known about the development of pyramidal cell dendrites and spines in other cortical layers. Here we studied dendritic morphology of layer-V pyramidal cells in primary visual cortex (V1, sensory), cytoarchitectonic area TE in the inferotemporal cortex (sensory association), and granular prefrontal cortex (Walker's area 12, executive) of macaque monkeys at the ages of 2 days, 3 weeks, 3.5 months, and 4.5 years. We found that changes in the basal dendritic field area of pyramidal cells were different across the three areas. In V1, field size became smaller over time (largest at 2 days, half that size at 4.5 years), in TE it did not change, and in area 12 it became larger over time (smallest at 2 days, 1.5 times greater at 4.5 years). In V1 and TE, the total number of branch points in the basal dendritic trees was similar between 2 days and 4.5 years, while in area 12 the number was greater in the adult monkeys than in the younger ones. Spine density peaked at 3 weeks and declined in all areas by adulthood, with V1 exhibiting a faster decline than area TE or area 12. Estimates of the total number of spines in the dendritic trees revealed that following the onset of visual experience, pyramidal cells in V1 lose more spines than they grow, whereas those in TE and area 12 grow more spines than they lose during the same period. These data provide further evidence that the process of synaptic refinement in cortical pyramidal cells differs not only according to time, but also location within the cortex. Furthermore, given the previous finding that layer-III pyramidal cells in all these areas exhibit the highest density and total number of spines at 3.5 months, the current results indicate that pyramidal cells in layers III and V develop spines at different rates.

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Section: Methodsmentioning

confidence: 85%

Postnatal Dendritic Growth and Spinogenesis of Layer-V Pyramidal Cells Differ between Visual, Inferotemporal, and Prefrontal Cortex of the Macaque Monkey

Oga

Elston²,

Fujita

2017

Front. Neurosci.

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“…TEav differs from adjacent, dorsal TE in terms of their connections and functions (visual memory vs visual perception: Saleem et al 2000;Suzuki and Amaral 2003). The net decrease in the total number of spines from the peak at 3.5M to adults was larger in the granular, dorsal TE (40 %) than in the dysgranular TEav Elston et al 2011). This value was much smaller in TEav (10 %) than in area 12 (46 %), TEO (56 %), V4 (73 %), V2 (78 %), V1 (76 %), and A1 (78 %) (Elston et al 2009(Elston et al , 2010a(Elston et al , b, 2011.…”

Section: Comparison With Old World Monkeysmentioning

confidence: 95%

“…Among the cortical areas previously investigated, the anterior ventral part of area TE (TEav) is the only cortical area with obscure layer IV (Elston et al 2011). TEav differs from adjacent, dorsal TE in terms of their connections and functions (visual memory vs visual perception: Saleem et al 2000;Suzuki and Amaral 2003).…”

Section: Comparison With Old World Monkeysmentioning

confidence: 99%

“…morphology. Previous studies have found that the developmental profiles of dendrites and spines differ across cortical areas and across species (Huttenlocher 1990;Huttenlocher and Dabholkar 1997;Jacobs et al 1997Jacobs et al , 2001Elston et al 2009Elston et al , 2010aElston et al , 2010bElston et al , 2011Petanjek et al 2008Petanjek et al , 2011Oga et al 2013;Bianchi et al 2013). In macaques, for example, the total number of spines in the basal dendrites of a layer III pyramidal cell is larger in the prefrontal cortical area 12 and temporal association area (TE) than in the primary visual area (V1) throughout development, and peaked at around 3.5 months after birth in all these areas (Elston et al 2009).…”

Section: Introductionmentioning

confidence: 96%

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Postnatal development of dendritic structure of layer III pyramidal neurons in the medial prefrontal cortex of marmoset

et al. 2014

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In the primate cerebral cortex, dendritic spines rapidly increase in number after birth up to infancy or mid-childhood, and then decrease towards adulthood. Abnormalities in these processes accompany several psychiatric disorders. In this study, we examined developmental changes of basal dendrites and spines of layer III pyramidal cells in the medial prefrontal cortex (mPFC) of the common marmoset. The mPFC consists of several areas with distinct features in layer organization, histochemistry, connections, and, in humans, vulnerability to psychiatric disorders. We selected three areas for examination: granular dorsomedial prefrontal (area 8B/9), dysgranular ventromedial prefrontal (area 14r), and agranular anterior cingulate (area 24) cortices. Dendritic field areas, lengths, number of branching points, and total spine number reached a peak at 2-3 postnatal months in all three areas. However, the profiles of spine formation and pruning differed across the three areas with different degrees of granularity; the amount of spine loss from the peak to adulthood was less in areas 24 (33%) and 14r (29%) than in area 8B/9 (43%). Disturbance of this modest spine pruning in the less granular cortical areas may lead to an excessive loss of spines reported for areas 24 and 14r of schizophrenic patients.

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“…There are considerable differences in the structure of pyramidal cells when considering the size and complexity of their dendritic arborization—the complexity of a dendritic arbor is evaluated as the total length of its dendritic branches along with the number and distribution of their branching points—in the density of dendritic spines on their dendritic branches and in the total number of dendritic spines. These differences are found not only between cortical areas, but also between different species, and these differences are thought to be critical for the functional specialization of the cortical areas (reviewed in Jacobs et al 2001; Elston 2007; Elston et al 2011; DeFelipe 2011; Eyal et al 2014; Mohan et al 2015). …”

Section: Introductionmentioning

confidence: 99%

Dendritic-branching angles of pyramidal neurons of the human cerebral cortex

et al. 2016

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In this article, we analyze branching angles of the basal dendrites of pyramidal neurons of layers III and V of the human temporal cortex. For this, we use a novel probability directional statistical distribution called truncated von Mises distribution that is able to describe more accurately the dendritic-branching angles than the previous proposals. Then, we perform comparative studies using this statistical method to determine similarities and/or differences between branches and branching angles that belong to different cortical layers and regions. Using this methodology, we found that common design principles exist and govern the patterns found in the different branches that compose the basal dendrites of human pyramidal cells of the temporal cortex. However, particular differences were found between supra and infragranular cells. Furthermore, we compared the branching angles of human layer III pyramidal neurons with data obtained in the previous studies in layer III of both the rat somatosensory cortex and of several cortical areas of the mouse. Finally, we study the branching angle differences between the humans that compose our data.Electronic supplementary materialThe online version of this article (doi:10.1007/s00429-016-1311-0) contains supplementary material, which is available to authorized users.

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Spinogenesis and Pruning in the Anterior Ventral Inferotemporal Cortex of the Macaque Monkey: An Intracellular Injection Study of Layer III Pyramidal Cells

Cited by 39 publications

References 184 publications

Postnatal Dendritic Growth and Spinogenesis of Layer-V Pyramidal Cells Differ between Visual, Inferotemporal, and Prefrontal Cortex of the Macaque Monkey

Postnatal Dendritic Growth and Spinogenesis of Layer-V Pyramidal Cells Differ between Visual, Inferotemporal, and Prefrontal Cortex of the Macaque Monkey

Postnatal development of dendritic structure of layer III pyramidal neurons in the medial prefrontal cortex of marmoset

Dendritic-branching angles of pyramidal neurons of the human cerebral cortex

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