Spinorial methods have proven to be a powerful tool to study geometric properties of Spin manifolds. We aim to continue the spinorial study of manifolds that are not necessarily Spin. We introduce and study the notion of G-invariance of generalised Spin r structures on a manifold M equipped with an action of a Lie group G. For the case when M is a homogeneous G-space, we prove a characterisation of the existence of these invariant structures in terms of a lift of the isotropy representation. As an application, we study the invariant generalised Spin r structures for all the homogeneous realisations of the spheres.