Spintronic Memristor as Interface Between DNA and Solid State Devices

Abstract

Recently biomolecular computing platforms have been widely investigated with great potentials in both biomedical research and practices, such as using molecular structures of DNA to present the data bits and to operate the logic. Emerging CMOS/molecular hybrid (CMOL) circuitry demonstrates many overwhelming advantages compared with pure biomolecular circuitry, including the design flexibility and compatibility with the traditional CMOS process. In this work, spintronic devices are utilized to detect the spatial information of DNA by translating the magnetic signals associated with the DNA pieces to electrical signals. The physical mechanisms and sensing performances of various magnetic sensor structures are discussed and evaluated, including giant magneto-resistance (GMR) spin valve sensors, tunnel magneto-resistance (TMR) sensors and our newly proposed spintronic GMR/TMR memristor sensors. A on-chip readout scheme is also proposed with a telecommunication method-frequency division multiplexing (FDM) technique to efficiently transmit useful information and filtrate the noise which could achieve high SNR up to 70 dB. The new approach can be adopted as not only the interface between the DNA structure and CMOS circuitry, but also a promising sensing mechanism in the DNA hybridization detection technique.

Extended Higher-Order Elements with Frequency-Doubled Parameters: The Hysteresis Loops Are Always of Type II

“…For example, the integration of memristors with MEMS is a promising way of improving the performance of collecting and processing data from sensors [ 26 , 27 , 28 ]. The contemporary literature describes many examples of the use of nano-memristive devices and nanowires for sensing or detecting temperature [ 29 ], gas [ 30 ], pH [ 31 ], cancer markers [ 32 ], DNA [ 33 , 34 ], UV-light [ 13 ], glucose [ 35 ], proteins [ 36 ], or, for example, for wearable non-contact breath sensing [ 37 ]. A very promising direction for the integration of sensors and memristors is in-sensor computing with memristors [ 38 ].…”

Advent of Spintronics in Neuromorphic Computing Systems: A Study

“…The above arrangement describes memristor crossbar arrays, with the realization of operational mixed mode memristor or a CMOS cognitive chip [85] remains as the challenge to be addressed. Further based on this concept a new problem statement has formed, which is illustrated as: If memristor helps to realize memory, then how spin will help to perform in-memory computing?.…”