SPION and doxorubicin-loaded polymeric nanocarriers for glioblastoma theranostics

Luque-Michel, Edurne; Lemaire, Laurent; Blanco-Prieto, María J.

doi:10.1007/s13346-020-00880-8

Cited by 22 publications

(11 citation statements)

References 34 publications

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“…Dual drug delivery and imaging nanoscale delivery systems, which are often termed theranostics, can be useful for both therapeutic and diagnostic purposes. Luque-Michel et al developed theranostic polymeric nanoparticles loaded with SPIONs and doxorubicin to treat glioma-bearing mice [ 47 ]. They found significant particle accumulation when the animal is under static magnetic field and the accumulation was easily imaged using MRI.…”

Section: Treatmentmentioning

confidence: 99%

Magnetic Nanoparticles in Biology and Medicine: Past, Present, and Future Trends

et al. 2021

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The use of magnetism in medicine has changed dramatically since its first application by the ancient Greeks in 624 BC. Now, by leveraging magnetic nanoparticles, investigators have developed a range of modern applications that use external magnetic fields to manipulate biological systems. Drug delivery systems that incorporate these particles can target therapeutics to specific tissues without the need for biological or chemical cues. Once precisely located within an organism, magnetic nanoparticles can be heated by oscillating magnetic fields, which results in localized inductive heating that can be used for thermal ablation or more subtle cellular manipulation. Biological imaging can also be improved using magnetic nanoparticles as contrast agents; several types of iron oxide nanoparticles are US Food and Drug Administration (FDA)-approved for use in magnetic resonance imaging (MRI) as contrast agents that can improve image resolution and information content. New imaging modalities, such as magnetic particle imaging (MPI), directly detect magnetic nanoparticles within organisms, allowing for background-free imaging of magnetic particle transport and collection. “Lab-on-a-chip” technology benefits from the increased control that magnetic nanoparticles provide over separation, leading to improved cellular separation. Magnetic separation is also becoming important in next-generation immunoassays, in which particles are used to both increase sensitivity and enable multiple analyte detection. More recently, the ability to manipulate material motion with external fields has been applied in magnetically actuated soft robotics that are designed for biomedical interventions. In this review article, the origins of these various areas are introduced, followed by a discussion of current clinical applications, as well as emerging trends in the study and application of these materials.

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Section: Treatmentmentioning

confidence: 99%

Magnetic Nanoparticles in Biology and Medicine: Past, Present, and Future Trends

et al. 2021

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“…In biomedical diagnostic imaging, it is mainly used as a contrast agent to improve image contrast and as a tracer for the calibration of specific targets; in disease treatment, it can be used as a carrier for drug delivery, or an external magnetic field can be used to generate heat energy from magnetic nanoparticles injected into the body to kill cancer cells, which can alleviate damage to normal cells caused by traditional chemotherapy [24]. Superparamagnetic iron oxide properties provide the carrier with unique capabilities, such as magnetic guidance and MRI (Figure 2a) [25].…”

Section: Diagnosismentioning

confidence: 99%

Progress and Viewpoints of Multifunctional Composite Nanomaterials for Glioblastoma Theranostics

et al. 2022

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The most common malignant tumor of the brain is glioblastoma multiforme (GBM) in adults. Many patients die shortly after diagnosis, and only 6% of patients survive more than 5 years. Moreover, the current average survival of malignant brain tumors is only about 15 months, and the recurrence rate within 2 years is almost 100%. Brain diseases are complicated to treat. The reason for this is that drugs are challenging to deliver to the brain because there is a blood–brain barrier (BBB) protection mechanism in the brain, which only allows water, oxygen, and blood sugar to enter the brain through blood vessels. Other chemicals cannot enter the brain due to their large size or are considered harmful substances. As a result, the efficacy of drugs for treating brain diseases is only about 30%, which cannot satisfy treatment expectations. Therefore, researchers have designed many types of nanoparticles and nanocomposites to fight against the most common malignant tumors in the brain, and they have been successful in animal experiments. This review will discuss the application of various nanocomposites in diagnosing and treating GBM. The topics include (1) the efficient and long-term tracking of brain images (magnetic resonance imaging, MRI, and near-infrared light (NIR)); (2) breaking through BBB for drug delivery; and (3) natural and chemical drugs equipped with nanomaterials. These multifunctional nanoparticles can overcome current difficulties and achieve progressive GBM treatment and diagnosis results.

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“…There has been a recent increase in interest concerning the delivery of DOX and SPIONs. It was found that polymeric NPs carrying DOX and SPIONs accumulate in the tumor tissue of the treated mice, which in effect restricts the growth rate of the glioma [ 169 ]. PEGylated SPIONs loaded with DOX and ICG were also found to inhibit the growth of the tumor, prevent weight loss of the tested C6 glioma-bearing rats and elongate their survival time, while not presenting any significant side effects.…”

Section: Metal-based Nanoparticlesmentioning

confidence: 99%

Metal-Based Nanostructured Therapeutic Strategies for Glioblastoma Treatment—An Update

2022

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Glioblastoma (GBM) is the most commonly diagnosed and most lethal primary malignant brain tumor in adults. Standard treatments are ineffective, and despite promising results obtained in early phases of experimental clinical trials, the prognosis of GBM remains unfavorable. Therefore, there is need for exploration and development of innovative methods that aim to establish new therapies or increase the effectiveness of existing therapies. One of the most exciting new strategies enabling combinatory treatment is the usage of nanocarriers loaded with chemotherapeutics and/or other anticancer compounds. Nanocarriers exhibit unique properties in antitumor therapy, as they allow highly efficient drug transport into cells and sustained intracellular accumulation of the delivered cargo. They can be infused into and are retained by GBM tumors, and potentially can bypass the blood–brain barrier. One of the most promising and extensively studied groups of nanostructured therapeutics are metal-based nanoparticles. These theranostic nanocarriers demonstrate relatively low toxicity, thus they might be applied for both diagnosis and therapy. In this article, we provide an update on metal-based nanostructured constructs in the treatment of GBM. We focus on the interaction of metal nanoparticles with various forms of electromagnetic radiation for use in photothermal, photodynamic, magnetic hyperthermia and ionizing radiation sensitization applications.

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SPION and doxorubicin-loaded polymeric nanocarriers for glioblastoma theranostics

Cited by 22 publications

References 34 publications

Magnetic Nanoparticles in Biology and Medicine: Past, Present, and Future Trends

Magnetic Nanoparticles in Biology and Medicine: Past, Present, and Future Trends

Progress and Viewpoints of Multifunctional Composite Nanomaterials for Glioblastoma Theranostics

Metal-Based Nanostructured Therapeutic Strategies for Glioblastoma Treatment—An Update

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