Acute aortic dissection is an uncommon but lethal cause of acute chest, back, and abdominal pain. Establishing a timely diagnosis is paramount, as mortality from acute aortic dissection rises by the hour. Physical findings are protean and may include acute aortic valve insufficiency, peripheral pulse deficits, a variety of neurologic deficits, or end-organ ischemia. The keys to establishing a timely diagnosis are maintaining a high index of suspicion and quickly obtaining a diagnostic study. CT angiography, magnetic resonance imaging, transesophageal echocardiography, and, to a lesser extent, aortography are all highly accurate imaging modalities. The choice of study should be driven by the clinical stability of the patient, the information required and the resources available at presentation. KEYWORDS: aortic diseases, chest pain, hypertensive emergency, shock, Marfan syndrome, adrenergic beta-antagonists, vascular surgery, thoracic surgery A ortic dissection is an uncommon but highly lethal disease with an incidence of approximately 2,000 cases per year in the United States. 1 It is often mistaken for less serious pathology. In one series, aortic dissection was missed in 38% of patients at presentation, with 28% of patients first diagnosed at autopsy. 2 Early recognition and management are crucial. If untreated, the mortality rate for acute aortic dissection increases by approximately 1% per hour over the first 48 hours and may reach 70% at 1 week. As many as 90% of untreated patients who suffer aortic dissection die within 3 months of presentation. 3,4 Generally, cardiothoracic surgeons or cardiologists experienced with managing aortic dissection should direct patient evaluation and treatment. Hospitalists, however, are increasingly assuming responsibility for the initial triage and management of patients with acute chest pain syndromes and therefore must be able to rapidly identify aortic dissection, initiate supportive therapy, and refer patients to appropriate specialty care.
PATHOPHYSIOLOGYAortic dissection occurs when layers of the aortic wall separate because of infiltration of high-pressure arterial blood. The proximate causes are elevated shear stress across the aortic lumen in the setting of a concomitant defect in the aortic media. Shear stress is caused by the rapid increase in luminal pressure per unit of time (dP/dt) that results from cardiac systole. As the aorta
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