The purpose of this study was to examine the relationship between religiosity, spirituality, sexual attitudes, and sexual behaviors among Latino and non-Latino college students. The sample included 230 undergraduate college students enrolled at a mid-sized University in the western USA. Sexual behaviors among Latinos were significantly correlated with sexual attitudes and spiritual disclosure in close relationships. However, sexual behaviors for non-Latino respondents were only significantly related to sexual attitudes, not indices of religiousness or spirituality. Sexual educators, health educators, college-level instructors, and counselors can use these results to help Latino and non-Latino students alike understand the relationship between their religious and spiritual beliefs, sexual attitudes, and sexual behaviors.