Spirometric reference values for white European children and adolescents: Polgar revisited

Quanjer, P. H.; Borsboom, Gerard; Brunekreef, Bert; Zach, M; Forche, G; Cotes, J. E.; Sanchís, J.; Paoletti, Paolo

doi:10.1002/ppul.1950190209

Cited by 188 publications

(194 citation statements)

References 12 publications

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“…Subjects were prepped with electrodes for continuous monitoring with a 12-lead electrocardiogram (MAX 1, SensorMedics Corp.) and fitted with a nose clip and mouthpiece assembly for measurement of oxygen uptake (VO 2 ) and carbon dioxide production by open-circuit spirometry (SensorMedics V max ). Variables measured included VO 2 , carbon dioxide, heart rate, blood pressure (BP), respiratory exchange ratio, and spirometry parameters (27).…”

Section: Methodsmentioning

confidence: 99%

Impaired aerobic exercise adaptation in children and adolescents with craniopharyngioma is associated with hypothalamic involvement

Piguel¹,

Ábrahám²,

Bouhours‐Nouet³

et al. 2012

European Journal of Endocrinology

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Objective: Many patients treated for craniopharyngioma (CP) complain of a relative incapacity for physical activity. Whether this is due to an objective decrease in adaptation to exercise is unclear.We assessed exercise tolerance in children with surgically treated CP and appropriate pituitary hormone replacement therapy compared with healthy controls and we examined the potential relationships with hypothalamic involvement, GH replacement, and the catecholamine deficiency frequently observed in these subjects. Design and methods: Seventeen subjects (12 males and five females) with CP and 22 healthy controls (14 males and eight females) aged 15.3G2.5 years (7.3-18 years) underwent a standardized cycle ergometer test. Maximum aerobic capacity was expressed as the ratio of VO 2max to fat-free mass (VO 2max /FFM), a measure independent of age and fat mass in children. Results: VO 2max /FFM was 20% lower in children with CP compared with controls (P!0.05), even after adjustment for gender. Children with hypothalamic involvement (nZ10) had a higher percentage of fat mass (P!0.05) than those without hypothalamic involvement (nZ7) and lower VO 2max /FFM (P!0.05), whereas children without hypothalamic involvement had VO 2max /FFM close to that of controls (PO0.05). GH treatment was associated with a significant positive effect on aerobic capacity (P!0.05) only in the absence of hypothalamic involvement. No relationship was found between exercise capacity parameters and daily urine epinephrine excretion or epinephrine peak response to insulin-induced hypoglycemia. Conclusions: Children with CP have a decrease in aerobic capacity mainly related to hypothalamic involvement. The hypothalamic factors altering aerobic capacity remain to be determined.

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Section: Methodsmentioning

confidence: 99%

Impaired aerobic exercise adaptation in children and adolescents with craniopharyngioma is associated with hypothalamic involvement

Piguel¹,

Ábrahám²,

Bouhours‐Nouet³

et al. 2012

European Journal of Endocrinology

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“…Values were expressed as % of predicted based on published reference data (31), and considered to be abnormal if below the 5 th percentile (32,33). Total lung capacity (TLC) and residual volume (RV) were determined from body plethysmography and expressed as a ratio (RV/TLC).…”

Section: Measurements and Proceduresmentioning

confidence: 99%

Follow-up Study of a Randomized Controlled Trial of Postnatal Dexamethasone Therapy in Very Low Birth Weight Infants: Effects on Pulmonary Outcomes at Age 8 to 11 Years

Nixon

Washburn

Schechter

et al. 2007

The Journal of Pediatrics

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Objective-To determine if postnatal dexamethasone (DEX) exposure affects pulmonary outcomes at school-age in children born with very low birth weight (VLBW).Study design-Follow-up study of 68 VLBW children who participated in a randomized controlled trial (RCT) of postnatal DEX. Pulmonary function was assessed by spirometry. Current asthma status was obtained from a parent.Results-Sixty-eight % of the placebo group had below normal forced expiratory volume in 1 second (FEV 1 ) compared to 40% of the DEX group (X 2 = 4.84, p=.03), with trends for lower forced vital capacity (FVC) and FEV 1 values in the placebo group. Fifty % of placebo group and 34% of DEX group had below normal FEV 1 /FVC (X 2 =1.59; p =.21). Parent-reported prevalence of asthma did not differ between groups. Logistic regression analysis suggested that the positive effects of DEX on pulmonary function at follow-up were mediated in part by shortened postnatal exposure to mechanical ventilation.Conclusions-Postnatal DEX exposure was associated with higher expiratory flow with no adverse effects on pulmonary outcomes at school-age. The prevalence of asthma and impaired pulmonary function underscore the influence of neonatal illness on health at school age, and stress the importance of repeated follow-up examinations of these children. Keywordsprematurity; chronic lung disease; bronchopulmonary dysplasia; children; corticosteroid; lung function asthma Approximately 1.5% of infants are born prematurely each year with very low birth weight (VLBW) (birth weight < 1501 grams) (1), and about 19-23% of these infants will develop chronic lung disease (CLD) (2,3). A diagnosis of CLD has been associated with greater Address correspondence to: Patricia A. Nixon, Ph.D., Wake Forest University, HES Dept. P.O. Box 7868, Winston-Salem, NC 27109-7868, Phone (336) Fax (336) 758-4680, Email nixonpa@wfu.edu. edited by AJ and WFB Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. hospital readmission rates for respiratory morbidity during the first five years of life (4), increased odds of asthma (4) and respiratory symptoms in childhood (5), and reduced pulmonary function in infancy (6), childhood (7,8), adolescence (9), and young adulthood (10) compared to their VLBW peers without CLD. Systematic reviews indicate that treatment of VLBW infants with corticosteroids, primarily dexamethasone (DEX), in the first few weeks of life significantly decreases duration of ventilator dependence and the incidence of CLD (11-13). The beneficial effects of postnatal corticosteroids on the lung are believed to be related to reduce...

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“…1983). The forced expiratory volume in 1 second (FEVd) Pulmonary function after childhood ALL 23 Rosenthal et al 1993;Quanjer et al 1995: Stam et al 1996 to fit 348 healthy 13-to 24-year-old Caucasian subjects who had never smoked from a local population study (Nysom et al 1997 (Altman, 1991). Probabilities below 0.05 were considered statistically significant and data were analysed using the SAS computer software package (SAS Institute.…”

Section: Pulmonary Function Testingmentioning

confidence: 99%

Pulmonary function after treatment for acute lymphoblastic leukaemia in childhood

Nysom

Holm²,

Olsen³

et al. 1998

Br J Cancer

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Summary The aim of this study was to examine pulmonary function after acute tymphoblastic leukaemia in childhood and identify risk factors for reduced pulmonary function. We studied a population-based cohort of 94 survivors of acute lymphoblastic leukaemia in childhood who were in first remission after treatment withut spinal irradiation or bone marrow transplantation. Pulmonary function test results were compared with reference values for our laboratory, based on 348 healthy subjects who had never smoked from a local population study. A median of 8 years after cessation of therapy (range 1-18 years) the participants had a slight, subclinical, restrictive ventilatory insufficiency and reduced transfer factor and transfer coefficient. The changes in lung function were related to younger age at treatment and to more doseintensive treatment protocols that specified rnore use of cranial irradiation and higher cumulative doses of anthracyclines, cytosine arabinoside and intravenous cyclophosphamide than previous protocols. We conclude that, 8 years after treatment without bone marrow transplantation or spinal irradiation, survivors of childhood acute lymphoblastic leukaemia in first remission were without pulmonary symptoms but had signs of slight restrictive pulmonary disease including reduced transfer factor. The increased dose intensity of many recent protocols for childhood acute tymphoblastic leukaemia may lead to increased late pulmonary toxicity.

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Spirometric reference values for white European children and adolescents: Polgar revisited

Cited by 188 publications

References 12 publications

Impaired aerobic exercise adaptation in children and adolescents with craniopharyngioma is associated with hypothalamic involvement

Impaired aerobic exercise adaptation in children and adolescents with craniopharyngioma is associated with hypothalamic involvement

Follow-up Study of a Randomized Controlled Trial of Postnatal Dexamethasone Therapy in Very Low Birth Weight Infants: Effects on Pulmonary Outcomes at Age 8 to 11 Years

Pulmonary function after treatment for acute lymphoblastic leukaemia in childhood

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