Spirometry Results after 6-Month Follow-up in a Prospective Pediatric Cohort Diagnosed with SARS-CoV-2 Infection

Antoniadi, Marita; Vitoratou, Dimitra-Irinna; Koletsi, Patra; Mermiri, Despina-Zoe; Papadopoulou, Athina; Kostaridou, Stavroula

doi:10.1007/s12098-022-04275-0

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“…In a study of 77 children after acute COVID-19, 69 (89%) participants had normal physical examination findings and normal spirometry. Four of the participants had asthma, and none had a significant change in lung function from baseline ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

The Impact of SARS-CoV-2 Infection on Symptom Control and Lung Function in Children with Asthma

et al. 2023

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Rationale Little is known about the long-term impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on children with asthma. Objectives To determine whether SARS-CoV-2 infection affects symptom control and lung function in children with asthma. Methods Using data from clinical registries and the electronic health record, we conducted a prospective case-control study of children with asthma aged 6–21 years who had (cases) or did not have (control subjects) SARS-CoV-2 infection, comparing baseline and follow-up asthma symptom control and spirometry within an ∼18-month time frame and, for cases, within 18 months of acute coronavirus disease (COVID-19). Results A total of 171 cases had baseline and follow-up asthma symptom data, and 114 cases had baseline and follow-up spirometry measurements. There were no significant differences in asthma symptom control ( P = 0.50), forced expiratory volume in 1 second ( P = 0.47), forced vital capacity ( P = 0.43), forced expiratory volume in 1 second/forced vital capacity ( P = 0.43), or forced expiratory flow, midexpiratory phase ( P = 0.62), after SARS-CoV-2 infection. Compared with control subjects (113 with symptom data and 237 with spirometry data), there were no significant differences in follow-up asthma symptom control or lung function. A similar proportion of cases and control subjects had poorer asthma symptom control (17.5% vs. 9.7%; P = 0.07) or worse lung function (29.0% vs. 32.5%; P = 0.50) at follow-up. Patients whose asthma control worsened after COVID-19 had a shorter time to follow-up (3.5 [1.5–7.5] vs. 6.1 [3.1–9.8] mo; P = 0.007) and were more likely to have presented with an asthma exacerbation during COVID-19 (46% vs. 26%; P = 0.04) than those without worse control. Conclusions We found no significant differences in asthma symptom control or lung function in youth with asthma up to 18 months after acute COVID-19, suggesting that COVID-19 does not affect long-term asthma severity or control in the pediatric population.

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Section: Discussionmentioning

confidence: 99%