Spirulina: an example of cyanobacteria as nutraceuticals

Ohmori, Masayuki; Ehira, Shigeki

doi:10.1002/9781118402238.ch7

Cited by 8 publications

(3 citation statements)

References 82 publications

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“…11 Spirulina platensis (Arthrospira platensis, Phormidiaceae) is a blue-green alga/cyanobacterium widely used as a nutraceutical and pharmaceutical agent. 12 It has become an interesting subject for many investigations conducted either in vitro and/ or in vivo since it is a valuable food source of antioxidants with high-quality proteins, amino acids, vitamins (A, B 1 , B 2 , B 3 , B 6 , C, E, and K and folate), beta-carotene and other pigments, phenolic acids, minerals (magnesium, zinc, manganese, and selenium) as well as macro-and micronutrients, including unsaturated fatty acids, polysaccharides, and carbohydrates. 12,13 Other findings showed that it is nontoxic, inexpensive, almost without side effects compared to synthetic products, 14 and it is used as a bioactive feed additive.…”

Section: Introductionmentioning

confidence: 99%

“…12 It has become an interesting subject for many investigations conducted either in vitro and/ or in vivo since it is a valuable food source of antioxidants with high-quality proteins, amino acids, vitamins (A, B 1 , B 2 , B 3 , B 6 , C, E, and K and folate), beta-carotene and other pigments, phenolic acids, minerals (magnesium, zinc, manganese, and selenium) as well as macro-and micronutrients, including unsaturated fatty acids, polysaccharides, and carbohydrates. 12,13 Other findings showed that it is nontoxic, inexpensive, almost without side effects compared to synthetic products, 14 and it is used as a bioactive feed additive. 15 Due to its antioxidant properties, spirulina has been shown to have protective effects against drugs or chemicals-induced cardiotoxicity, hepatoxicity, and nephrotoxicity.…”

Section: Introductionmentioning

confidence: 99%

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Protective effects of spirulina against hemato-biochemical alterations, nephrotoxicity, and DNA damage upon lead exposition

et al. 2020

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The current study was aimed at exploring the protective efficacy of spirulina against the hemato-biochemical alterations and nephrotoxicity induced by lead (Pb). Female rats aged 12 weeks were treated for 4 weeks with Pb (0.344 g kg−1 bw) associated or not with spirulina (5.3 g kg−1 bw). Renal damage induced by Pb was related to a severe anemia, increases of oxidative stress-related parameters (thiobarbituric acid reactive substances (TBARS) (+29%), protein carbonyl (PCO) (+66.3%), and advanced oxidation protein product (AOPP) (+110%)), plasma lactate dehydrogenase (LDH) (+80%), creatinine and urea levels in plasma, and uric acid concentration in urine, as well as genotoxic changes (+89.3% and +60% for DNA and mRNA levels, respectively). Conversely, LDH and antioxidant enzyme activities in kidney were decreased, as well as the levels of plasma uric acid, and urinary creatinine and urea levels. Spirulina-supplemented rats exhibited normal peripheral blood and renal parameters and renal histology. It can be suggested that Arthrospira platensis alleviates damages induced by Pb, thanks to its high phenolic content and antioxidant capacity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective effects of spirulina against hemato-biochemical alterations, nephrotoxicity, and DNA damage upon lead exposition

et al. 2020

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“…Arthrospira species are the source of high-value nutraceuticals (e.g., Spirulina) and natural blue pigments in food (e.g., the phycobiliprotein, C -phycocyanin) [68,69]. They tolerate high levels of alkalinity and can be cultured in a variety of closed or open (e.g., race way pond) environments.…”

Section: “Non-model” Species: Requirements For Uptake and Genetic mentioning

confidence: 99%

Emerging Species and Genome Editing Tools: Future Prospects in Cyanobacterial Synthetic Biology

et al. 2019

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Recent advances in synthetic biology and an emerging algal biotechnology market have spurred a prolific increase in the availability of molecular tools for cyanobacterial research. Nevertheless, work to date has focused primarily on only a small subset of model species, which arguably limits fundamental discovery and applied research towards wider commercialisation. Here, we review the requirements for uptake of new strains, including several recently characterised fast-growing species and promising non-model species. Furthermore, we discuss the potential applications of new techniques available for transformation, genetic engineering and regulation, including an up-to-date appraisal of current Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated protein (CRISPR/Cas) and CRISPR interference (CRISPRi) research in cyanobacteria. We also provide an overview of several exciting molecular tools that could be ported to cyanobacteria for more advanced metabolic engineering approaches (e.g., genetic circuit design). Lastly, we introduce a forthcoming mutant library for the model species Synechocystis sp. PCC 6803 that promises to provide a further powerful resource for the cyanobacterial research community.

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