Spirulina platensis attenuates the associated neurobehavioral and inflammatory response impairments in rats exposed to lead acetate

Khalil, Samah R.; Khalifa, Hesham A.; Abdel-Motal, Sabry M.; Mohammed, Hesham H.; Elewa, Yaser Hosny Ali; Mahmoud, Hend A.

doi:10.1016/j.ecoenv.2018.03.068

Cited by 43 publications

(26 citation statements)

References 72 publications

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“…LUT: luteolin; PbAc: lead acetate; mRNA: messenger RNA; Gapdh: glyceraldehyde-3-phosphate dehydrogenase Previous studies indicated that Pb exposure activated microglia and enhanced the release of proinflammatory cytokines in these cells. 40 Our results are consistent with the data of Khalil et al 7 and Shvachiy et al 41 Oxidative stress-induced premature senescence in the astrocytes that may be accountable for their production of pro-inflammatory cytokines. 42 Exposure to Pb stimulates phosphorylation of NF-kB that transactivated from cytoplasm into nucleus, stimulating the activation of downstream proinflammatory genes.…”

Section: Discussionsupporting

confidence: 91%

“…These histopathological findings suggest that PbAc induces cell death, which was confirmed by an elevation in the oxidative stress markers in the PbAc-intoxicated rats. Khalil et al 7 reported that Pb readily crosses the BBB and directly alerted BBB structure, which further leads to morphological and functional changes in the brain architecture. However, LUT preventing the pathological Figure 7.…”

Section: Discussionmentioning

confidence: 99%

“…5 Although the pathophysiology of neurotoxicity produced following heavy metals exposure remains unclear, it is well identified that Pb-induced neuronal injury is correlated with oxidative challenge, neuroinflammation, and the enhancement of programmed cell death, which may play an important role in the development of the neurodegenerative diseases. 1,6,7 Therefore, searching for natural agents with a wide spectrum of health-promoting capacities including antioxidant and anti-inflammatory activities may provide a neuroprotective effect against Pb-induced neuronal damage. Luteolin (LUT; 3 0 ,4 0 ,5,7-tetrahydroxy flavones) is a glycosylated flavonoid compound found in different fruits and vegetables such as celery, broccoli, perilla leaf, pepper, honeysuckle bloom, and chamomile tea.…”

Section: Introductionmentioning

confidence: 99%

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Neuroprotective role of luteolin against lead acetate-induced cortical damage in rats

et al. 2020

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Luteolin (LUT) is a glycosylated flavonoid compound that has multiple beneficial pharmacological and biological impacts. The current investigation was undertaken to evaluate the putative neuroprotective potency of LUT against neuronal damage induced by lead acetate (PbAc). Twenty-eight rats were placed into four equal groups. Group 1: served as the control group, group 2: rats were supplemented orally with LUT (50 mg kg−1), group 3: rats were intraperitoneally injected with PbAc (20 mg kg−1), and group 4: rats were pretreated with LUT before PbAc injection with the same doses. All animals were treated for 7 days. The exposure to PbAc increased the concentration of lead in the cortical tissue, neuronal lipid peroxidation, and nitric oxide (NO) production and decreased the antioxidant enzymes. Additionally, PbAc enhanced a neuroinflammatory response in the cortical tissue through increasing the pro-inflammatory cytokines secretion and inducible NO synthase expression. Moreover, cortical cell death was recorded following PbAc intoxication as evidenced by the enhancement of the proapoptotic and inhibiting the antiapoptotic markers. Interestingly, LUT supplementation reversed the cortical adverse reactions induced by PbAc. Taken together, these findings may suggest that LUT may be useful for attenuating neuronal damage induced by PbAc through inhibiting the oxidative damage, neuroinflammation, and the cortical cell death.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neuroprotective role of luteolin against lead acetate-induced cortical damage in rats

et al. 2020

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“…This modulation was associated with down-regulation of the mRNA expression profile of genes that mediate the inflammatory response in the kidney tissue. Previously, various antioxidants of natural sources have shown an ameliorative efficacy against xenobiotics-induced toxicity in in vivo animal studies [11,[37][38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Ethanolic Extract of Moringa oleifera Leaves Influences NF-κB Signaling Pathway to Restore Kidney Tissue from Cobalt-Mediated Oxidative Injury and Inflammation in Rats

et al. 2020

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This study aimed to describe the protective efficacy of Moringa oleifera ethanolic extract (MOEE) against the impact of cobalt chloride (CoCl2) exposure on the rat’s kidney. Fifty male rats were assigned to five equal groups: a control group, a MOEE-administered group (400 mg/kg body weight (bw), daily via gastric tube), a CoCl2-intoxicated group (300 mg/L, daily in drinking water), a protective group, and a therapeutic co-administered group that received MOEE prior to or following and concurrently with CoCl2, respectively. The antioxidant status indices (superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH)), oxidative stress markers (hydrogen peroxide (H2O2), 8-hydroxy-2-deoxyguanosine (8-OHdG), and malondialdehyde (MDA)), and inflammatory response markers (nitric oxide (NO), tumor necrosis factor (TNF-α), myeloperoxidase (MPO), and C-reactive protein (CRP)) were evaluated. The expression profiles of pro-inflammatory cytokines (nuclear factor-kappa B (NF-kB) and interleukin-6 (IL-6)) were also measured by real-time quantitative polymerase chain reaction (qRT-PCR). The results showed that CoCl2 exposure was associated with significant elevations of oxidative stress and inflammatory indices with reductions in the endogenous tissue antioxidants’ concentrations. Moreover, CoCl2 enhanced the activity of the NF-κB inflammatory-signaling pathway that plays a role in the associated inflammation of the kidney. MOEE ameliorated CoCl2-induced renal oxidative damage and inflammatory injury with the suppression of the mRNA expression pattern of pro-inflammatory cytokine-encoding genes. MOEE is more effective when it is administered with CoCl2 exposure as a prophylactic regimen. In conclusion, MOEE administration exhibited protective effects in counteracting CoCl2-induced renal injury in rats.

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“…2,3 Also, Hg 2+ promotes the apoptosome formation with the consequent activation of the caspases 3 and 9, which in the end will promote the renal cell death. 1,4,33,34 Recent evidence suggests that Spirulina reduces the expression of caspase 3 in lead causes neurotoxicity 35 and cyclosporine- or gamma radiation causes nephrotoxicity. 36 Moreover, the phycocyanin reduces the mitochondrial dysfunction which prevents apoptosis events in cell culture, 37 as well as phycocyanin, reduced the caspases 3 and 9 expressions on cisplatin-induced nephrotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Phycobiliproteins and phycocyanin of Arthrospira maxima (Spirulina) reduce apoptosis promoters and glomerular dysfunction in mercury-related acute kidney injury

Rojas-Franco

Franco-Colín

Meléndez-Camargo

et al. 2018

Toxicology Research and Application

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Arthrospira maxima (Spirulina) is considered a nutraceutical or functional food because it provides health benefits and it is used as nephroprotector because it contains nucleophilic compounds as phycobiliproteins and phycocyanin that prevent oxidative stress and cellular damage process. Also, it is known that inorganic mercury is bioaccumulated and exerted kidney toxicity. Despite the nephroprotective effect of Spirulina and its components, there is not enough information about the effect of them on renal function as well as the apoptosis process inhibition. This work aimed to investigate whether phycobiliproteins and phycocyanin of Spirulina can improve HgCl 2 -related glomerular and tubular renal dysfunction as well as the Bax, Bcl 2 , and effectors caspases alterations. Male mice were administrated with Spirulina, phycobiliproteins or phycocyanin 30 min before 5 mg/Kg HgCl 2 administration. The nutraceuticals were administrated for the next 5 days. Then, the mice were euthanized. The renal function, caspases 3 and 9 activities, as well as Bax and Bcl 2 expression were evaluated. Spirulina and its components prevent HgCl 2 -related apoptosis induction and glomerular dysfunction. We concluded that phycobiliproteins and phycocyanin of Spirulina reduce glomerular damage but not the tubular dysfunction in a mercury-related acute kidney injury.

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Spirulina platensis attenuates the associated neurobehavioral and inflammatory response impairments in rats exposed to lead acetate

Cited by 43 publications

References 72 publications

Neuroprotective role of luteolin against lead acetate-induced cortical damage in rats

Neuroprotective role of luteolin against lead acetate-induced cortical damage in rats

Ethanolic Extract of Moringa oleifera Leaves Influences NF-κB Signaling Pathway to Restore Kidney Tissue from Cobalt-Mediated Oxidative Injury and Inflammation in Rats

Phycobiliproteins and phycocyanin of Arthrospira maxima (Spirulina) reduce apoptosis promoters and glomerular dysfunction in mercury-related acute kidney injury

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