Spirulina platensis enhances immune status, inflammatory and oxidative markers of HIV patients on antiretroviral therapy in Cameroon

Moor, Vicky Jocélyne Ama; Pieme, Constant Anatole; Nkeck, Jan René; Nya, Prosper Cabral Biapa; Mondinde, Georges Ikomey; Kouanfack, Charles; Assoumou, Marie Claire Okomo; Ngogang, Jeanne

doi:10.21203/rs.2.22360/v1

Cited by 4 publications

(4 citation statements)

References 15 publications

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“…However, there is limited information on the investigation of SP confirming the mechanism of antioxidant and anti-inflammatory effects and the impact on the quality of life in the HIV-positive population taking HAART. Thus far, it has been shown that supplementation with Spirulina platensis could improve the immune status of HIV patients on ART and decrease inflammatory and pro-oxidant levels [ 190 ]. The development of more clinical studies to confirm the SP protective effect in this population will answer many questions.…”

Section: Combined and Synergistic Therapeutic Actions Of Haart And Spmentioning

confidence: 99%

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The Potential of Spirulina platensis to Ameliorate the Adverse Effects of Highly Active Antiretroviral Therapy (HAART)

2022

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The human immunodeficiency virus (HIV) is one of the most prevalent diseases globally. It is estimated that 37.7 million people are infected with HIV globally, and 8.2 million persons are infected with the virus in South Africa. The highly active antiretroviral therapy (HAART) involves combining various types of antiretroviral drugs that are dependent on the infected person’s viral load. HAART helps regulate the viral load and prevents its associated symptoms from progressing into acquired immune deficiency syndrome (AIDS). Despite its success in prolonging HIV-infected patients’ lifespans, the use of HAART promotes metabolic syndrome (MetS) through an inflammatory pathway, excess production of reactive oxygen species (ROS), and mitochondrial dysfunction. Interestingly, Spirulina platensis (SP), a blue-green microalgae commonly used as a traditional food by Mexican and African people, has been demonstrated to mitigate MetS by regulating oxidative and inflammatory pathways. SP is also a potent antioxidant that has been shown to exhibit immunological, anticancer, anti-inflammatory, anti-aging, antidiabetic, antibacterial, and antiviral properties. This review is aimed at highlighting the biochemical mechanism of SP with a focus on studies linking SP to the inhibition of HIV, inflammation, and oxidative stress. Further, we propose SP as a potential supplement for HIV-infected persons on lifelong HAART.

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Section: Combined and Synergistic Therapeutic Actions Of Haart And Spmentioning

confidence: 99%

“…The development of more clinical studies to confirm the SP protective effect in this population will answer many questions. The recommended concentrations of SP for daily supplementation varies, as studies have successfully used 19 g [ 185 ], 5 g [ 186 ], and 10 g [ 190 , 191 ].…”

Section: Combined and Synergistic Therapeutic Actions Of Haart And Spmentioning

confidence: 99%

The Potential of Spirulina platensis to Ameliorate the Adverse Effects of Highly Active Antiretroviral Therapy (HAART)

2022

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“…The use of spirulina nutritional supplements in patients with HIV receiving antiretroviral therapy (62 people) reduced the viral load and reduced the levels of TNF-α and prooxidant markers. Moor et al [153] suggest daily use of spirulina in treating patients with HIV infection, which can improve the state of the immune status and reduce the level of inflammation and prooxidants. and, more importantly, TNF-α.…”

Section: Effects Of Microalgae and Cyanobacteria Polysaccharides On T...mentioning

confidence: 99%

Antiviral Effects and Mechanisms of Action of Water Extracts and Polysaccharides of Microalgae and Cyanobacteria

Беседнова

Andryukov

Кузнецова

et al. 2022

J. Pharm. Nutr. Sci.

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Microalgae (MA) and cyanobacteria (CB) are currently attracting much attention from scientists due to the high biological activity of many secondary metabolites of these aquatic organisms. This review presents up-to-date modern data on the prospects for using polysaccharides (PS) of these marine aquatic organisms as effective and practically safe antiviral agents. These natural biopolymers are polyvalent compounds, which allows them to bind to several complementary biological target receptors. Particular emphasis is placed on the exopolysaccharides (EPS) Spirulina sp. (Arthrospira sp.), Porphyridium sp., Chlorella sp., and Euglena sp., whose antiviral activity makes them promising for the creation of drugs, biologically active food supplements, and products for functional nutrition. The mechanisms of the biological action of PS and the targets of these compounds are presented with a brief description of PS's anti-inflammatory, immunomodulatory and antioxidant actions, which make the most significant contribution to the antiviral effects. The authors hope to draw the attention of researchers to the use of water extracts and polysaccharides of microalgae and cyanobacteria as potential broad-spectrum antiviral agents that can become the basis for new antivirus strategies.

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“…S. platensis is commercially produced because of its high digestibility and interesting protein content (46-71%) of the dry weight of the algae, as well as high amounts of essential fatty acids and amino acids, vitamins, pigments (phycobiliproteins and carotenoids) and polysaccharides (Zhu et al, 2018;Corrêa and Teixeira, 2021). This cyanobacterium has gained in importance and international demand not only for its nutritional and therapeutic properties but also for its applications in human and animal nutrition, therapeutics and diagnostics (Panjiar et al, 2017;Ama Moor et al, 2020). It is generally recognized as safe from the US Food and Drug Administration and considered as the most complete food for the future by the Food and Agriculture Organization of the United Nations (Goulamabasse, 2018;Branyikova and Lucakova, 2020).…”

Section: Introductionmentioning

confidence: 99%

Physiological and biochemical traits, antioxidant compounds and some physico-chemical factors of Spirulina platensis cultivation as influenced by Moringa oleifera leaves extract culture medium enriched with sodium bicarbonate and kanwa

Oscar¹,

Fils²,

Kennedy³

et al. 2021

Afr. J. Biotechnol.

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The prospects for using Moringa oleifera leaves extract (MLE) supplemented with different concentrations of kanwa or sodium bicarbonate (NaHCO 3 ) as a low-cost alternative growth medium of Spirulina platensis were evaluated in a small-scale outdoor cultivation system. The present study was aimed to evaluate the potential of MLE growth medium enriched with different concentrations (4 or 8 g L -1) of kanwa and NaHCO 3 on growth, chlorophyll content, biochemical characteristics, antioxidant compounds and some physico-chemical factors. Jourdan's standard medium was taken as control. The results showed that the growth parameters such as cell population, biomass dry weight, cell productivity and specific growth rate were positively affected in MLE cultivation medium enriched with kanwa or NaHCO 3 at different concentration levels. The addition of urea, kanwa or NaHCO 3 in MLE cultivation medium at different concentration levels increased significantly (p< 0.05) the protein content, the peroxidase and polyphenol oxidase activity, the conductivity, pH, total dissolved solids and salinity from 20 to 25 days of cultivation whereas a decrease in carbohydrate and phenol content was recorded during all the period of the experimentation. The highest values of growth parameters were notably in MLE medium supplemented with urea and kanwa at 8 g L -1. The MLE medium enriched with urea and kanwa at 8 g L -1 was shown to be an appropriate growth medium that can be used as a lowcost alternative growth medium for commercial cultivation of S. platensis.

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Spirulina platensis enhances immune status, inflammatory and oxidative markers of HIV patients on antiretroviral therapy in Cameroon

Cited by 4 publications

References 15 publications

The Potential of Spirulina platensis to Ameliorate the Adverse Effects of Highly Active Antiretroviral Therapy (HAART)

The Potential of Spirulina platensis to Ameliorate the Adverse Effects of Highly Active Antiretroviral Therapy (HAART)

Antiviral Effects and Mechanisms of Action of Water Extracts and Polysaccharides of Microalgae and Cyanobacteria

Physiological and biochemical traits, antioxidant compounds and some physico-chemical factors of Spirulina platensis cultivation as influenced by Moringa oleifera leaves extract culture medium enriched with sodium bicarbonate and kanwa

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