2024
DOI: 10.21203/rs.3.rs-4290857/v1
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Spirulina platensis peptide-loaded nanoliposomes alleviate hepatic lipid accumulation in Male Wistar Rats by influencing redox homeostasis and lipid metabolism via the AMPK signaling pathway

katayoon karimzadeh,
Suraj Unniappan,
Asgar Zahmatkesh

Abstract: Spirulina platensis low-molecular-weight peptides (SP) have been reported to exhibit antioxidant and hepatoprotective properties. However, the limited bioavailability and solubility of SPs limit their potential applications. In this study, to examine the potential anti-obesity effects and underlying mechanisms of SPs, high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) model rats were treated with SPs and SP-loaded nanoliposomes. Furthermore, hepatic biochemical parameters, inflammatory markers, his… Show more

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