A low-cost, intelligent data acquisition system for quartz crystal microbalance (QCM) and other (superficial SAW and bulk acoustic wave) resonator-based chemical and biosensors described in this article. The system is based on the novel modified method of the dependent count and allows obtaining high metrological performances: programmable and constant in all frequency range relative error of measurement up to 0,0005 % (5 ppm); nonredundant, reduced conversion time of measurement and wide frequency range from 0.05 Hz to 9 MHz (144 MHz with prescaling). The developed system allows measuring variations of the resonance frequency shift for QCM sensors working in liquids and gases. The described low-cost data acquisition system is based on novel integrated circuit of universal frequency-to-digital converter. This design approach has eliminated much of the hardware: there is no need for a microcontroller and complex sensor interfacing electronics, as it is directly compatible with PC computers.