Spleen conserving surgery versus splenectomy for injured patients with splenic trauma

Coldwell, Christopher; Hollingsworth, Andrew

doi:10.1002/14651858.cd009042.pub2

Cited by 1 publication

(1 citation statement)

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“…The indications for splenectomy are well established in medical literature. Given the spleen's crucial role in the body's immune mechanisms, there has been a gradual shift towards preserving the spleen, even in cases of severe (grade IV) splenic trauma [ 1 ]. In the context of hemolytic anemia, the spleen is pivotal in the removal of deformed RBCs from circulation through processes known as pitting and culling, which leads to an enlargement of the spleen [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Splenectomy in Thalassemia: The Role of Surgery as an Adjunct to Medical Management

Kumar,

Chauhan

2024

Cureus

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Introduction Beta thalassemia is a hemoglobinopathy characterized by defective production of the beta chain of hemoglobin, leading to irreversible destruction of RBCs, splenomegaly, pancytopenia, and a requirement for multiple transfusions. This condition necessitates iron chelation therapy, and splenectomy is often performed to manage hypersplenism. Methods This report includes a series of seven diagnosed cases of beta thalassemia with hypersplenism, all of whom underwent open splenectomy. Preoperative transfusions were administered to achieve target hemoglobin and platelet counts of 9 g/dL and 50,000/µL, respectively. Results The study included seven patients diagnosed with beta thalassemia, all of whom underwent open splenectomy. Among these, three patients also had concomitant cholecystectomy due to the presence of gallstones. The primary indication for performing splenectomy was hypersplenism. Preoperative transfusions were administered to ensure target hemoglobin levels of 9 g/dL and platelet counts of 50,000/µL. All patients were successfully discharged with minimal morbidity and no reported mortality. The longest follow-up period observed in this series was 10 months post-splenectomy, which limited the assessment of long-term effects. Conclusion Open splenectomy for hypersplenism in patients with beta thalassemia appears to be a safe and effective procedure with minimal short-term morbidity and no mortality observed in this series. However, due to the limited follow-up duration, the long-term effects of splenectomy in these patients could not be evaluated. Further studies with longer follow-up are needed to assess the long-term outcomes of splenectomy in beta thalassemia patients.

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Section: Introductionmentioning

confidence: 99%