Spleen injury following left extracorporeal shockwave lithotripsy (ESWL)

Marinkovic, Serge P.; Marinkovic, Christina M.; Xie, Donghua

doi:10.1186/1471-2490-15-4

Cited by 15 publications

(9 citation statements)

References 3 publications

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“…Sarcosine has previously been reported to be associated with prostate cancer 26 , but subsequent studies showed no association with aggressiveness 42 43 44 . In our study, sarcosine was detected in high abundance.…”

Section: Discussionmentioning

confidence: 98%

Metabolite Analysis and Histology on the Exact Same Tissue: Comprehensive Metabolomic Profiling and Metabolic Classification of Prostate Cancer

Huan

Troyer

2016

Sci Rep

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We report a method of metabolomic profiling of intact tissue based on molecular preservation by extraction and fixation (mPREF) and high-performance chemical isotope labeling (CIL) liquid chromatography mass spectrometry (LC-MS). mPREF extracts metabolites by aqueous methanol from tissue biopsies without altering tissue architecture and thus conventional histology can be performed on the same tissue. In a proof-of-principle study, we applied dansylation LC-MS to profile the amine/phenol submetabolome of prostate needle biopsies from 25 patient samples derived from 16 subjects. 2900 metabolites were consistently detected in more than 50% of the samples. This unprecedented coverage allowed us to identify significant metabolites for differentiating tumor and normal tissues. The panel of significant metabolites was refined using 36 additional samples from 18 subjects. Receiver Operating Characteristic (ROC) analysis showed area-under-the-curve (AUC) of 0.896 with sensitivity of 84.6% and specificity of 83.3% using 7 metabolites. A blind study of 24 additional validation samples gave a specificity of 90.9% at the same sensitivity of 84.6%. The mPREF extraction can be readily implemented into the existing clinical workflow. Our method of combining mPREF with CIL LC-MS offers a powerful and convenient means of performing histopathology and discovering or detecting metabolite biomarkers in the same tissue biopsy.

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Section: Discussionmentioning

confidence: 98%

Metabolite Analysis and Histology on the Exact Same Tissue: Comprehensive Metabolomic Profiling and Metabolic Classification of Prostate Cancer

Huan

Troyer

2016

Sci Rep

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“…However, the phenomenon of splenic rupture secondary to trauma caused by ESWL is an exceptional occurrence [1]. On a worldwide literature search, there have been only 11 published cases of splenic injury associated with ESWL since the inception of the shock wave technology in 1980 [10][11][12][13][14][15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Massive Hemoperitoneum Secondary to Splenic Laceration After Extracorporeal Shockwave Lithotripsy

Salih

Turan

Bakal

et al. 2020

Cureus

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Extracorporeal shock wave lithotripsy (ESWL) is considered a safe technique, but not without complications, though the vast majority are minor complications. We describe a rare case of splenic injury after ESWL. A 33-year-old male presented to the emergency department (ED) after three weeks experiencing severe intermittent left-sided flank pain that he contributed to a previous motor vehicle accident. Then computerized tomography (CT) revealed a left renal stone. ESWL was performed after three weeks. After being discharged home, he returned the same day to the ED with persistent, worsening abdominal pain, hypotension, and multiple syncopes. CT demonstrated the presence of active contrast extravasation from the spleen likely due to active bleeding. Initial resuscitation was with intravenous fluids and blood products. The following day, the embolization of the splenic artery was done. The patient was discharged home after nine days of conservative management. After one month, he had shortness of breath due to a large left-sided pleural effusion and lung collapse managed with thoracocentesis and thoracoscopic surgery. Subsequent follow-up reveals much improvement and successful conservative management. Splenic injury is a rare complication of ESWL, and all of the 11 reported cases in the literature were managed with splenectomy. Our case is unique in being successfully managed conservatively.

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“…After ESWL was implemented it was supposed that 85% of all patients with kidneys stones could be cured by nonsurgical means [10]. The initial promising results of ESWL were challenge with common side effects caused by this procedure, such as bleeding, severe pain, or urinary tract infections [9], rare complications, such as spleen rupture or intrarenal hematoma [11,12,13], and long-term medical effects: hypertension and diabetes mellitus [14,15,16].…”

Section: Kidney Stone Diseasementioning

confidence: 99%

Treatment of Kidney Stone Disease, Benign Prostatic Hyperplasia and Chronic Prostatitis with Thermobalancing Therapy should be listed in the Guidance for Health Professionals

2018

ARC Journal of Urology

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The prevalence of kidney stone disease, chronic prostatitis / chronic pelvic pain syndrome (CP/CPPS) and benign prostatic hyperplasia (BPH) increases around the world. Long-term medications and surgical procedures for these non-life-threatening chronic conditions can develop serious side effects and complications. At the same time, Thermobalancing therapy (TT) with Dr Allen's therapeutic Device (DATD) has shown its high effectiveness in the treatment of chronic internal diseases. Discussion at many international conferences in 2017-2018 was aimed at treating various chronic non-malignant diseases with the help of Thermobalancing therapy, such as BPH, CP/CPPS, kidney stones and cardiovascular diseases. In the conferences were presented cases of TT with DATD of patients with kidney stone disease that confirm the ability of DATD to dissolve any type and size of kidney stone; discussed the outcomes from the clinical trials of TT in 124 men with BPH and 45 patients with CP/CPPS, before and after 6-month period they used DATD. The assured results of the cases and clinical trials reveal that TT with DATD treats the cause of kidney stone disease, CP/CPPS and BPH. Implementation of this therapy is needed today, as it helps patients avoid long-term drugs and surgical procedures, including extracorporeal shock wave lithotripsy (ESWL) with their risks and complications. In addition, it is a cost-effective solution. Therefore, conference participants proposed that TT with DATD should be included in the Guidance for health professionals.

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Spleen injury following left extracorporeal shockwave lithotripsy (ESWL)

Cited by 15 publications

References 3 publications

Metabolite Analysis and Histology on the Exact Same Tissue: Comprehensive Metabolomic Profiling and Metabolic Classification of Prostate Cancer

Metabolite Analysis and Histology on the Exact Same Tissue: Comprehensive Metabolomic Profiling and Metabolic Classification of Prostate Cancer

Massive Hemoperitoneum Secondary to Splenic Laceration After Extracorporeal Shockwave Lithotripsy

Treatment of Kidney Stone Disease, Benign Prostatic Hyperplasia and Chronic Prostatitis with Thermobalancing Therapy should be listed in the Guidance for Health Professionals

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