Spleen Regulates Hematopoietic Stem/Progenitor Cell Functions Through Regulation of EGF in Cirrhotic Hypersplenism

Wang, Peijun; Li, Zhenzhen; Ren, Shengxiang; Li, Jiangwei; Yang, Jun; Kong, Guangyao; Jiang, An; Li, Zongfang

doi:10.1007/s10620-018-5091-7

Cited by 5 publications

(2 citation statements)

References 29 publications

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“…The cell-cell interaction analysis found that the main interaction cells in HS are epithelial cells and HSC. Peripheral blood cell reduction is one of the most common complications of HS and the spleen can regulate the function of HSC by regulating EGF signals through epithelial cells ( 62 ). However, Lu et al ( 38 )found that epithelial cells can directly contact HSC to function through the MERFISH spatial transcriptome.…”

Section: Discussionmentioning

confidence: 99%

Single-cell RNA Sequencing Analysis Reveals New Immune Disorder Complexities in Hypersplenism

et al. 2022

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Hypersplenism (HS) is a concomitant symptom of liver or blood disease. Not only does the treatment of HS face challenges, but the transcriptome of individual cells is also unknown. Here, the transcriptional profiles of 43,037 cells from four HS tissues and one control tissue were generated by the single-cell RNA sequencing and nine major cell types, including T-cells, B-cells, NK cells, hematopoietic stem cells, neutrophil cells, mast cells, endothelial cells, erythrocytes, and dendritic cells were identified. Strikingly, the main features were the lack of CCL5+ B-cells in HS and the presence of SESN1+ B cells in HS with hepatocellular carcinoma (HS-HCC). In cell-cell interaction analysis, CD74-COPA and CD94-HLA-E in HS were found to be up-regulated. We further explored HS-specifically enriched genes (such as FKBP5, ADAR, and RPS4Y1) and found that FKBP5 was highly expressed in HCC-HS, leading to immunosuppression. Taken together, this research provides new insights into the genetic characteristics of HS via comprehensive single-cell transcriptome analysis.

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Section: Discussionmentioning

confidence: 99%

Single-cell RNA Sequencing Analysis Reveals New Immune Disorder Complexities in Hypersplenism

et al. 2022

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“…Among them, a characteristic symptom of HLD is chronic liver damage, which furtherly develops into cirrhosis and portal hypertension. Subsequently, splenomegaly and hypersplenism can occur, leading to pancytopenia, especially the platelets (PLT) (5)(6)(7). Because HLD is a hereditary disease, anti-copper drugs need to be taken for a long time or even for lifelong.…”

Section: Introductionmentioning

confidence: 99%

Platelet safety range before splenectomy for hypersplenism : based on 244 cases of splenectomy in hepatolenticular degeneration patients

Wang

Feng

Peng

et al. 2021

AGEB

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Background and study aims : To investigate the safety and efficacy of splenectomy for hepatolenticular degeneration (HLD) patients with PLT less than 20 × 109/L. Patients and methods : A total of 244 HLD patients with hyper-splenism underwent splenectomy. According to the preopera-tive PLT values, the patients were divided into three groups : group A of 53 patients with PLT < 20 × 109/L ; group B of 92 patients with 20 × 109/L ≤ PLT ≤ 30 × 109/L ; group C of 99 patients with PLT > 30 × 109/L. General information including : blood cell counts, liver function , coagulation function 1 day before sugery and 1, 7, 14 days after surgery ; intraoperative blood loss ; operation time ; vital signs at the beginning, at 60 minutes and the end of the operation. Pressure and blood oxygen ; postoperative drainage ; postoperative complications and mortality. Results : Blood cell counts, liver function, and coagulation func-tion were improved after splenectomy in three groups (P<0.05) ; there was no significant difference in blood loss, operation time, vital signs during the operation, postoperative drainage, postoper-ative complications and mortality between three groups (P>0.05). Conclusion : For HLD patients with hypersplenism, it is safe and effective to conduct splenectomy under PLT < 20 × 109/L.

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Metabolomic analysis of serum reveals the potential effective ingredients and pathways of Danggui Buxue Tang in promoting erythropoiesis

Wang

Bei

et al. 2020

Complementary Therapies in Medicine

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Spleen Regulates Hematopoietic Stem/Progenitor Cell Functions Through Regulation of EGF in Cirrhotic Hypersplenism

Abstract: The spleen can regulate the functions of HSPCs in CH patients by regulating EGF signaling. EGF may be a therapeutic target for CH treatment.

Cited by 5 publications

References 29 publications

Single-cell RNA Sequencing Analysis Reveals New Immune Disorder Complexities in Hypersplenism

Single-cell RNA Sequencing Analysis Reveals New Immune Disorder Complexities in Hypersplenism

Platelet safety range before splenectomy for hypersplenism : based on 244 cases of splenectomy in hepatolenticular degeneration patients

Metabolomic analysis of serum reveals the potential effective ingredients and pathways of Danggui Buxue Tang in promoting erythropoiesis

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