Splenectomy for non-haematological metastatic malignant disease

Splenic metastasis from colorectal cancers is a very rare occurrence. Few cases have been reported in the literature. We report herein an additionnal case of metachronous splenic metastasis from adenocarcinoma of the sigmoid colon, 3 years after the diagnosis of the primary tumor. A 62-year old woman presented for regular follow-up after colectomy for sigmoid colon adenocarcinoma. A computed tomography-scan found two splenic metastatic nodules for which splenectomy had been performed. The histological analysis of the resected spleen showed a well-differentiated metastatic adenocarcinoma from colon. The patient recovered well after surgery, and 10 months after, she had no signs of the disease.

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“…The main sites of primary tumors that metastasize to spleen are lung, colon and rectum, ovary, malignant melanoma or breast [3, 5]. …”

Section: Discussionmentioning

confidence: 99%

“…The main primary sites of these tumors are breast, lung, skin, ovary or colon/rectum [2, 3]. Metastasis from colon are very uncommon, and the left colon is usually the source of these tumors [1–3]. Despite its rich vasculature, the spleen is very rarely involved by metastasis.…”

Section: Introductionmentioning

confidence: 99%

An unusual site of metastasis: splenic metastastasis from a colon cancer

et al. 2016

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“…Spencer and associates observed that in patients with ovarian cancer, when abdomen was irradiated with 20 Gy, splenic atrophia wasnt observed [30]. In another study of 20 Gy splenic radiotherapy, due to Howell-Jolly bodies in blood, similar effects to splenectomy were seen [43]. Splenic atrophy was seen mostly after 2-40 Gy [16,29,44].…”

Section: The Spleen In Radiation Dose-volume Relationshipmentioning

confidence: 95%

Which is the best? Palliative Radiation Therapy to Spleen or Splenectomy

Cihan¹

2018

J Radiol Oncol

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“…10 In other studies, splenic metastases are mostly associated with choriocarcinoma, malignant melanoma and lung, breast, gastric, pancreas and ovarian cancer. In lymphoma, lesions are usually multiple and smaller than 1 cm, but large, solitary lesion and splenomegaly may be seen on CT. 1,6,7,[15][16][17][18][19] In lymphoma, solid lesions may also be seen in the spleen on US. 20 In our study, more solid lesions with splenomegaly on US and multiple hypodense lesions with splenomegaly on CT were seen in lymphoma patients.…”

Section: 7mentioning

confidence: 99%

“…18 Other studies detected that the sensitivity of CT was between 37-91% and specificity is 96% and the sensitivity of US was 54-63% and the specificity was 99-100% in detecting splenic involvement of lymphoma. [21][22][23] However, to our knowledge there is no study showing sensitivity and specificity data of CT and US in solid malignancies.…”

Section: 7mentioning

confidence: 99%

Splenic Malignant Lesions in Lymphoma and Solid Tumors, A Comparative Study of Imaging Techniques.

Ozen¹

2015

UHOD

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Splenic involvement guide treatment and affect prognosis in lymphoma and solid tumors. The most common used imaging techniques in detecting splenic involvement are Ultrasound (US) and Computed Tomography (CT). In this study, our aims were to evaluate the imaging findings regarding the spleen, compare splenic lesions according to the diagnosis and evaluate correlations between US and CT according to splenomegaly and lesions. Between May 2008 and April 2011 we identified 72 patients with splenic lesions or splenomegaly on CT or US. However, we exclude 27 patients from the study because of study protocol. Therefore, we enrolled 45 patients with a proven malignancy who had splenic lesions detected with CT. Seventeen patients had a diagnosis of lymphoma, and 28 patients had non-hematological malignancies. The characteristic features of the splenic lesions, detected on CT in patients with a proven malignancy, varied according to the cancer type. Multiple splenic lesions and splenomegaly in lymphoma patients and only solitary lesions in solid tumors were seen on CT (p< 0.001). Lymphoma patients usually had a solid splenic lesion with splenomegaly on US, but no lesion in solid tumors were seen on US (p< 0.05). The US and CT correlation ratio was inferior for solid tumors.US may miss splenic solid tumor metastases. CT is useful for distinguishing splenic lymphoma involvement from solid tumor metastases. CT seems superior to US in detecting splenic solid tumor metastases.Keywords: Spleen, Ultrasound, Computed Tomography, Lymphoma, Solid Malignancies ÖZET Lenfoma ve Solid Tümörlerde Dalağın Malign Lezyonları, Görüntüleme Teknikleri Kıyaslama ÇalışmasıLenfoma ve solid tümörlerde dalak tutulumu prognozu etkilemekte ve tedaviye klavuzluk etmektedir. Dalak tutulumunun tanımlanmasında en sık kullanılan görüntüleme teknikleri Ultrason (US) ve Bilgisayarlı Tomografi (BT)'dir. Bu çalışmada dalağın görüntüleme bulgularını değerlendirmeyi, tanıya göre dalak lezyonlarını kıyaslamayı ve splenomegali ve lezyonlara göre US ve BT arasındaki korelasyonu değerlendirmeyi amaçladık. Mayıs 2008 ve Nisan 2011 arasında BT veya US'de splenomegali veya dalak lezyonları olan 72 hasta tanımladık. Ancak, 27 hastayı çalışma protokolü nedeniyle çalışmadan çıkarttık. Sonuçta kanıtlanmış bir malignensisi olan ve BT ile dalakta lezyonu saptanmış 45 hastayı çalışmaya aldık. On yedi hastanın tanısı lenfoma, 28 hastanın tanısı ise hematolojik olmayan malignensi idi. Kanıtlanmış bir malignensisi olan hastalarda BT'de gözlenen dalak lezyonlarının karakteristik özel-likleri kanser tipine göre farklılık gösterdi. BT'de lenfoma hastalarında dalakta çok sayıda lezyonla birlikte splenomegali görülürken, solid tümörlerde yalnızca tek lezyon görüldü (p< 0.001). US'de lenfoma hastalarında genellikle bir solid lezyona eşlik eden splenomegali varken, solid tümörlerde US'de lezyon gözlenmedi (p< 0.05). US ve BT'nin korelasyon oranı solid tümörlerde düşüktü. US solid tümör metastazını gözden kaçırabilir. BT lenfomanın dalak tutulumunu solid tümörlerin dalak metas...

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Splenectomy for non-haematological metastatic malignant disease

Cited by 17 publications

References 67 publications

An unusual site of metastasis: splenic metastastasis from a colon cancer

An unusual site of metastasis: splenic metastastasis from a colon cancer

Which is the best? Palliative Radiation Therapy to Spleen or Splenectomy

Splenic Malignant Lesions in Lymphoma and Solid Tumors, A Comparative Study of Imaging Techniques.

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