Splenectomy in Patients with Sickle Cell Disease in Tabuk

Abstract

BACKGROUND:Sickle cell disease is a common genetic disease in Saudi Arabia; it is an autosomal recessive disorder characterized by production of abnormal hemoglobin S and is associated with high morbidity and mortality. Acute splenic sequestration is a life-threatening complication for this disease. Prophylactic splenectomy is the only effective strategy for preventing future life-threatening episodes.AIM:The aim of this study was to study hospital records for all children aged 2 to 12 year old with Sickle cell disease who underwent splenectomy in Tabuk in Saudi Arabia.METHODS:Records of 24 children (13 males, 11 females) who underwent splenectomy in surgery department of King Salman North West Armed Hospital, Tabuk, Saudi Arabia between 2008 and 2015 were reviewed retrospectively and analyzed for age, sex, indications for splenectomy, surgical technique, preoperative and postoperative length of stay, operative and postoperative complications, acute chest syndrome, painful crises, blood transfusion and fever (preoperative and postoperative).RESULTS:We stressed on the information about the details of operation, the frequency of blood transfusion, fever, acute chest syndrome and painful crisis before and after operation.CONCLUSION:Here we found that blood transfusion frequency decreased after splenectomy.

Enhanced Bacteremia in Dextran Sulfate-Induced Colitis in Splenectomy Mice Correlates with Gut Dysbiosis and LPS Tolerance

“…As the largest lymphatic organ, the spleen's functions are filtration of foreign matters from blood, antibody production, and bacteria control [1]. Removal of the spleen (splenectomy), mostly due to blunt splenic injury [2], hypersplenism [3,4], and functional hyposplenism [5][6][7] in some conditions (coeliac disease, inflammatory bowel disease, and sickle cell anemia) [8] can lead to several bacterial infections, including Klebsiella pneumoniae, Hemophilus influenzae, and Pseudomonas aeruginosa [5][6][7]. Although these bacteria could be found in the environment, they are encapsulated Gram-negative bacteria that could be found in the intestine [9].…”

Splenectomy perspective for non-malignant hematological disorders: A cross-sectional study in the Eastern Province of KSA

“…These findings are concordant with those from a previous study in Oman indicating that patients with SCD and beta thalassemia are more likely to have splenectomy than other hematological disorders. 10 This finding may be explained by the relatively high prevalence of SCD in the Mediterranean Basin the Middle East. 11 , 12 Moreover, we found that most patients with SCD underwent splenectomy at less than 18 years of age or between 30 and 39 years of age, unlike those with beta and alpha thalassemia, who underwent the procedure before the age of 30.…”

“…The data collection sheet was formulated according to several sources from the literature. 8 , 9 , 10 , 11 Descriptive statistics include the number, percentage, mean and standard deviation as appropriate. For comparisons, chi-square test or Fisher's exact test were applied.…”

The Correlation Between Surgical Procedures and Quality of Life Among Sickle Cell Disease Patients: A Perspective Saudi Study

“…A vaso-occlusive crisis is the most common presentation of SCD in patients, and it is responsible for major organ damage [ 5 ]. One of the earliest and most commonly affected organs is the spleen [ 8 ]. Splenic damage increases susceptibility to encapsulated organisms (for example, Streptococcus pneumoniae , Haemophilus influenzae , and Neisseria meningitidis ) and necessitates splenectomy and subsequent antibiotic prophylaxis [ 9 , 10 ].…”