Splenectomy in plasma cell dyscrasias: A review of the clinical practice

Kapoor, Prashant; Singh, Ekta; Radhakrishnan, Priya; Mehta, Paulette

doi:10.1002/ajh.20736

Cited by 11 publications

(4 citation statements)

References 46 publications

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“…For example, no splenic abscess was observed in a study including 540 intraabdominal abscess cases [12]. Furthermore, splenic abscesses associated with Felty syndrome, amyloidosis, intravenous drug use, hemoglobinopathies, and diabetes mellitus have been reported in the literature [8,10,[13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Splenic abscess caused by MRSA developing in an infarcted area: case report and literature review

Arslan

Batırel

Tabak

et al. 2011

Journal of Infection and Chemotherapy

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Section: Discussionmentioning

confidence: 99%

Splenic abscess caused by MRSA developing in an infarcted area: case report and literature review

Arslan

Batırel

Tabak

et al. 2011

Journal of Infection and Chemotherapy

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“…Splenectomy increases the risk of infection, with overwhelming post-splenectomy infection (OPSI) being one of the most worrisome complications. (135)(136)(137)(138). OPSI consists of fulminant sepsis caused by encapsulated bacteria and can occur even long after surgery.…”

Section: Pros and Cons Of Splenectomy: Clinical Impact In Atherogenesmentioning

confidence: 99%

Contribution of Extramedullary Hematopoiesis to Atherosclerosis. The Spleen as a Neglected Hub of Inflammatory Cells

et al. 2020

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Cardiovascular diseases (CVDs) incidence is becoming higher. This fact is promoted by metabolic disorders such as obesity, and aging. Atherosclerosis is the underlying cause of most of these pathologies. It is a chronic inflammatory disease that begins with the progressive accumulation of lipids and fibrotic materials in the blood-vessel wall, which leads to massive leukocyte recruitment. Rupture of the fibrous cap of the atherogenic cusps is responsible for tissue ischemic events, among them myocardial infarction. Extramedullary hematopoiesis (EMH), or blood cell production outside the bone marrow (BM), occurs when the normal production of these cells is impaired (chronic hematological and genetic disorders, leukemia, etc.) or is altered by metabolic disorders, such as hypercholesterolemia, or after myocardial infarction. Recent studies indicate that the main EMH tissues (spleen, liver, adipose and lymph nodes) complement the hematopoietic function of the BM, producing circulating inflammatory cells that infiltrate into the atheroma. Indeed, the spleen, which is a secondary lymphopoietic organ with high metabolic activity, contains a reservoir of myeloid progenitors and monocytes, constituting an important source of inflammatory cells to the atherosclerotic lesion. Furthermore, the spleen also plays an important role in lipid homeostasis and immunecell selection. Interestingly, clinical evidence from splenectomized subjects shows that they are more susceptible to developing pathologies, such as dyslipidemia and atherosclerosis due to the loss of immune selection. Although CVDs represent the leading cause of death worldwide, the mechanisms involving the spleenatherosclerosis-heart axis cross-talk remain poorly characterized.

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“…; after ligation of splenic arteries in animal models, traumatic splenectomy, or surgical removal in some splenic pathologies) [ 8 , 22 – 28 ]. In contrast, the gain of splenic function has been evidenced in splenomegaly patients [ 17 , 24 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

High-fat diet activates splenic NOD1 and enhances neutrophil recruitment and neutrophil extracellular traps release in the spleen of ApoE-deficient mice

Fernández-García

González-Ramos

Avendaño-Ortíz

et al. 2022

Cell. Mol. Life Sci.

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In the course of atherogenesis, the spleen plays an important role in the regulation of extramedullary hematopoiesis, and in the control of circulating immune cells, which contributes to plaque progression. Here, we have investigated the role of splenic nucleotide-binding oligomerization domain 1 (NOD1) in the recruitment of circulating immune cells, as well as the involvement of this immune organ in extramedullary hematopoiesis in mice fed on a high-fat high-cholesterol diet (HFD). Under HFD conditions, the absence of NOD1 enhances the mobilization of immune cells, mainly neutrophils, from the bone marrow to the blood. To determine the effect of NOD1-dependent mobilization of immune cells under pro-atherogenic conditions, Apoe−/− and Apoe−/−Nod1−/− mice fed on HFD for 4 weeks were used. Splenic NOD1 from Apoe−/− mice was activated after feeding HFD as inferred by the phosphorylation of the NOD1 downstream targets RIPK2 and TAK1. Moreover, this activation was accompanied by the release of neutrophil extracellular traps (NETs), as determined by the increase in the expression of peptidyl arginine deiminase 4, and the identification of citrullinated histone H3 in this organ. This formation of NETs was significantly reduced in Apoe−/−Nod1−/− mice. Indeed, the presence of Ly6G+ cells and the lipidic content in the spleen of mice deficient in Apoe and Nod1 was reduced when compared to the Apoe−/− counterparts, which suggests that the mobilization and activation of circulating immune cells are altered in the absence of NOD1. Furthermore, confirming previous studies, Apoe−/−Nod1−/− mice showed a reduced atherogenic disease, and diminished recruitment of neutrophils in the spleen, compared to Apoe−/− mice. However, splenic artery ligation reduced the atherogenic burden in Apoe−/− mice an effect that, unexpectedly was lost in Apoe−/−Nod1−/− mice. Together, these results suggest that neutrophil accumulation and activity in the spleen are driven in part by NOD1 activation in mice fed on HFD, contributing in this way to regulating atherogenic progression.

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Splenectomy in plasma cell dyscrasias: A review of the clinical practice

Cited by 11 publications

References 46 publications

Splenic abscess caused by MRSA developing in an infarcted area: case report and literature review

Splenic abscess caused by MRSA developing in an infarcted area: case report and literature review

Contribution of Extramedullary Hematopoiesis to Atherosclerosis. The Spleen as a Neglected Hub of Inflammatory Cells

High-fat diet activates splenic NOD1 and enhances neutrophil recruitment and neutrophil extracellular traps release in the spleen of ApoE-deficient mice

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