Splenectomy increases the number of circulating hematopoietic stem/progenitor cells in patients with hepatitis <scp>C</scp> virus‐associated liver cirrhosis

Masuya, Masahiro; Shiraki, Katsuya; Sugimoto, Kazushi; Yamamoto, Norio; Yoneda, Misao; Kanayama, Kazuki; Nishikawa, Kenichiro; Ino, Kazuko; Tawara, Isao; Ohishi, Kohshi; Sakurai, Hiroyuki; Usui, Masanobu; Shiraishi, Taizo; Isaji, Shuji; Takei, Yoshiyuki; Katayama, Naoyuki

doi:10.1111/hepr.12319

Cited by 6 publications

(7 citation statements)

References 50 publications

(101 reference statements)

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“…Therefore, decline of these factors by splenectomy and high albumin levels could promote liver regeneration, as shown in the present study. Moreover, splenectomy is thought to modulate hepatic stellate cells and immunological changes . We have also reported that splenectomy provided protective effects for liver failure and promoted liver regeneration, possibly owing to the downregulation of immediate early response genes and upregulation of the heat shock protein, heme oxygenase‐1 .…”

Section: Discussionmentioning

confidence: 96%

“…Moreover, the effects of splenectomy have been studied from many aspects. The spleen plays an important role in modulating hepatic stellate cell dynamics in patients with hepatitis C virus (HCV)‐associated chronic liver disease, and splenectomy may improve liver function in patients with LC . On the other hand, splenectomy may improve liver fibrosis and cause beneficial immunological changes in cirrhotic patients with hepatitis, and improvements in antitumor mechanisms can also be expected .…”

Section: Introductionmentioning

confidence: 99%

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Liver regeneration after splenectomy in patients with liver cirrhosis

Yamada

Morine

Imura

et al. 2015

Hepatology Research

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Liver regeneration after splenectomy in patients with liver cirrhosis

Yamada

Morine

Imura

et al. 2015

Hepatology Research

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“…The spleen is known to contribute extensively to blood regeneration in conditions of stress, such as anaemia or injury-induced stress erythropoiesis, or in response to infections, when HSPCs from the BM actively migrate into the spleen and proliferate there (Griseri et al, 2012;Harandi et al, 2010;Lenox et al, 2005;Masuya et al, 2014;O'Malley et al, 2005). The role of tissue-resident HSPCs in these responses has remained elusive.…”

Section: Discussionmentioning

confidence: 99%

“…The spleen, for example, was the first organ reported to contain stem and progenitor cells that are able to rescue irradiation-induced haematopoietic failure (Jacobson et al, 1951). Today, the splenic red pulp is recognized as one of the most common sites for EMH in response to haematopoietic challenges like anaemia (Harandi et al, 2010;Lenox et al, 2005;Perry et al, 2007), increased demand of blood cells during pregnancy (Inra et al, 2015;Maymon et al, 2006;Nakada et al, 2014;Oguro et al, 2017); and various pathologies, such as myeloproliferative disorders (O'Malley et al, 2005) and chronic inflammation/infection (Griseri et al, 2012;Masuya et al, 2014). Mechanistically, upon BM injury or stress, BM HSPCs traffic to the spleen and are attracted to specific stromal cells producing SCF and CXCL12 (Inra et al, 2015;Miwa et al, 2013;Wang et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Quantitative and molecular differences distinguish adult human medullary and extramedullary haematopoietic stem and progenitor cell landscapes

Mende

Bastos

Santoro

et al. 2020

Preprint

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In adults, the bone marrow (BM) is the main site of haematopoietic stem and progenitor cells (HSPCs) maintenance and differentiation. It is known that other anatomical sites can contribute significantly to blood production under stress conditions. However limited tissue availability restricts our knowledge on the cellular, molecular and functional composition of extramedullary HSPC pools in humans at steady state or under stress. Here we describe the landscape of human HSPC differentiation across the three major haematopoietic anatomical sites: BM, spleen and peripheral blood (PB), using matched tissues isolated from the same individuals. Single cell RNA-seq of 30,000 HSPCs and 700 phenotypic haematopoietic stem cells and multipotent progenitors (HSC/MPP) demonstrates significantly different dynamics of haematopoiesis between BM and extramedullary tissues. Lineage-committed progenitors of spleen and PB do not actively divide, whereas BM is the primary site of progenitor proliferation. The balance of differentiation in spleen and PB is skewed towards the lymphoid and erythroid lineages, whereas in BM it is tilted towards megakaryocytic and myeloid progenitors. Extramedullary tissues also harbour a molecularly defined subset of HSC/MPP not found in the BM, which is marked by a specific acto-myosin cytoskeletal signature and transcriptional priming for division and lineage differentiation. Collectively, our findings define a unique cellular and molecular structure of the haematopoietic landscape in extramedullary organs, positioned for rapid lineage-primed demand-adapted haematopoiesis. These data also provide a framework for better understanding of human extramedullary haematopoiesis in health and disease.

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“…In the current study, we futher confirmed the efficacy of splenectomy in the improvement of cytopenia associted with hypersplenism in WD patients with liver cirrhosis. Recently, literatures have shown that splenectomy can improve liver function in patients with liver cirrhosis caused by hepatitis C or by advanced hepatocellular carcinoma [ 31 , 32 , 33 ]. Here, we also show the long-term beneficial effect of splenectomy on liver function in WD patients with hypersplenism and liver cirrhosis, though the deterioration of liver function was observed shortly after splenectomy.…”

Section: Discussionmentioning

confidence: 99%

Successful Splenectomy for Hypersplenism in Wilson’s Disease: A Single Center Experience from China

Yang

Chen

et al. 2015

PLoS ONE

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Splenomegaly and pancytopenia are common in Wilson’s disease (WD) and splenectomy is one of the conventional treatments for splenomegaly and the associated pancytopenia. However, splenectomy remained controversial for hypersplenism in WD as it was reported that splenectomy leaded to serious emotional and neurological deterioration in WD patients with hypersplenism. In the current study, we present our experiences in 70 WD patients with hypersplenism who had undergone splenectomy, outlining the safety and efficacy of splenectomy in WD. The clinical database of 70 WD patients with hypersplenism who had undergone splenectomy in our hospital between 2009 and 2013 were reviewed and followed-up regularly. Before splenectomy, all the patients accepted a short period of anti-copper treatment with intravenous sodium 2, 3-dimercapto-1-propane sulfonate (DMPS). All the patients demonstrated a marked improvement in platelet and leucocyte counts after splenectomy. No severe postoperative complication was observed. In particular, none of the 37 patients with mixed neurologic and hepatic presentations experienced neurological deterioration after splenectomy, and none of the patients with only hepatic presentations newly developed neurological symptoms. During the one year follow-up period, no patient presented hepatic failure or hepatic encephalopathy, no hepatic patient newly developed neurological presentations, and only 3 patients with mixed neurologic and hepatic presentations suffered neurological deterioration and these 3 patients had poor compliance of anti-copper treatment. Quantative analysis of the neurological symptoms in the 37 patients using the Unified Wilson’s Disease Rating Scale (UWDRS) showed that the neurological symptoms were not changed in a short-term of one week after splenectomy but significantly improved in a long-term of one year after splenectomy. Additionally, compared to that before splenectomy, the esophageal gastric varices in most patients significantly improved one year after splenectomy. Thus, we may conclude that splenectomy is a safe and effective therapeutic measure for hypersplenism in WD patients who had been preoperatively treated with DMPS for powerful anti-copper therapy.

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Splenectomy increases the number of circulating hematopoietic stem/progenitor cells in patients with hepatitis C virus‐associated liver cirrhosis

Abstract: Our data suggest that the spleen plays an important role in modulating HSC dynamics in patients with HCV-associated chronic liver disease. Our results also imply that splenectomy may improve liver function in patients with LC.

Cited by 6 publications

References 50 publications

Liver regeneration after splenectomy in patients with liver cirrhosis

Liver regeneration after splenectomy in patients with liver cirrhosis

Quantitative and molecular differences distinguish adult human medullary and extramedullary haematopoietic stem and progenitor cell landscapes

Successful Splenectomy for Hypersplenism in Wilson’s Disease: A Single Center Experience from China

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