Splenic, hepatic, renal and pulmonary clearance dysfunction associated with high-energy X-rays

Faria, Fernando P.; Petroianu, Andy; Mota, Luciene G.; Fernandes, Simone Odília Antunes; Geraldo, Jony Marques; Nascimento, Clara B.; Vital, Kátia Duarte

doi:10.1080/09553002.2022.2020360

Cited by 1 publication

(3 citation statements)

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“…2). The number of KCs with carbon pigments in their cytoplasm was reduced in the animals of both irradiated groups when compared to the control group (p < 0.05); however, no difference was observed between the irradiated groups (Table 1), which is in agreement with previous work with technetium-phytate 9 . The splenic macrophages containing carbon pigments were uniformly distributed in the splenic parenchyma of the control group.…”

Section: Resultssupporting

confidence: 91%

“…Previously, the same group of this work has published that the high-energy XR, used in radiotherapy, modifies the splenic clearance, enhancing the amount of marginal zone macrophages containing colloid particles 8 . Studies with technetiumphytate confirmed the splenic clearance modification in irradiated animals, revealing an enhancement of nearly 260% of the splenic uptake activity 9 . There was also reduction of the hepatic uptake activity of nearly 90%, which motivated the present histological investigation of the liver in view of potential radiation-induced damage to its parenchyma.…”

Section: Introductionmentioning

confidence: 78%

“…This study aimed to verify the megavoltage radiotherapy effects on RES, based on the previous results, which have shown that the concentration of the colloidal uptake activity in the splenic marginal zone after irradiation with a single dose of high-energy XR 8 , as well as a reduction of the hepatic uptake of a technetium-phytate solution injected in the animals 9 . The reduction of the hepatic uptake activity might be related with radiation-induced damage to the liver parenchyma that was histologically investigated in this work.…”

Section: Discussionmentioning

confidence: 99%

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Megavoltage radiotherapy effects on organs of the reticuloendothelial system

Pereira,

Petroianu,

Geraldo

et al. 2023

Acta Cir. Bras.

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Purpose: To study the uptake capacity of cells from the reticuloendothelial system after irradiation with high-energy X-rays. Methods: Eighteen male Wistar rats were distributed in three groups: group A (n = 6): control, unirradiated animals studied alongside animals from group B; group B (n = 6) and group C (n = 6): animals irradiated and studied after 24 and 48 hours, respectively. The rats were anesthetized and placed on a 10 MV linear accelerator. Next, they were irradiated in the abdominal region, with 8 Gy. Twenty-four (groups A and B) and 48 hours later (group C), a colloidal carbon solution (1 mL/kg) was intravenously injected in the tail vein. Fifty minutes later, the spleens and livers were withdrawn and prepared to be studied. Kupffer cells and splenic macrophages containing carbon pigments were counted in an optical microscope. Arithmetic means were calculated for each group and compared among them. Results: X-rays were associated with a reduced number of Kupffer cells containing colloidal carbon, proliferation and enlargement of biliary ducts, hypoplasia, and hepatocyte necrosis. In the irradiated spleen, the colloidal carbon uptake was concentrated in the marginal zone around the white pulp, with an inexpressive uptake of pigments by macrophages from white and red pulps. Conclusions: The X-rays in the rat abdomen are associated with a reduction in the Kupffer cells uptake of colloidal carbon, hepatocyte disorders, bile duct proliferation, and splenic uptake of colloidal carbon concentrated in the marginal zone.

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Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 78%