Splenic infarction and malaria

Norman, Francesca; Rojas-Marcos, Jorge; Hermida-Donate, José-Manuel; Monge‐Maíllo, Begoña; Perez-Molina, José A.; López‐Vélez, Rogelio

doi:10.1093/trstmh/tru095

Cited by 13 publications

(10 citation statements)

References 17 publications

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“…Most commonly, it presents as abdominal pain located in the left upper abdomen or sometimes in the epigastrium [8,10]. Diagnosis confirmation is made with contrast CT of the abdomen, which is more sensitive than the abdominal ultrasound [11]. They are seen as peripheral wedge areas that do not enhance with contrast [12].…”

Section: Discussionmentioning

confidence: 99%

Splenic Infarct Secondary to High Altitude Exposure in Sickle Cell Trait Patients: A Case Series

González

Shapiro

Tafur

et al. 2020

Cureus

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The sickle cell trait is considered a benign entity that generally does not show clinical manifestations. However, some complications have been described under certain conditions, such as a decrease in oxygen level, dehydration, and strenuous physical efforts. Among them, splenic infarct is a rare complication that presents as left upper abdominal pain in a situation of stress such as high altitude exposure. We present two cases of splenic infarcts in patients with undiagnosed sickle cell trait who showed to our institution with severe abdominal pain after coming from high altitude cities.

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Section: Discussionmentioning

confidence: 99%

Splenic Infarct Secondary to High Altitude Exposure in Sickle Cell Trait Patients: A Case Series

González

Shapiro

Tafur

et al. 2020

Cureus

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“…In this study, 27 (26.7%) patients were classi ed with miscellaneous systemic infections, with intracellular organisms representing the causative pathogens in most of these cases. Malaria and babesiosis have previously been reported to cause SI [17,18]. Both are parasitic diseases in which the parasites infect red blood cells (RBCs).…”

Section: Discussionmentioning

confidence: 99%

Splenic Infarction and Infectious Diseases in Korea

Chung²,

Lee

et al. 2020

Preprint

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BackgroundThe spleen contains immune cells and exhibits a pattern of infarction different from other organs; as such, splenic infarction (SI) may provide important clues to infection. However, the nature of the relationship between SI and infectious disease(s) is not well understood. Accordingly, this retrospective study investigated the relationship between SI and infection. MethodsHospital records of patients with SI, who visited Inha University Hospital (Incheon, Republic of Korea) between January 2008 and December 2018, were reviewed. Patient data regarding clinical presentation, causative pathogens, risk factors, and radiological findings were collected and analyzed.ResultsOf 353 patients with SI, 101 with infectious conditions were enrolled in this study, and their data were analyzed to identify associations between SI and infection. Ten patients were diagnosed with infective endocarditis (IE), and 26 exhibited bacteremia without IE. Twenty-seven patients experienced systemic infection due to miscellaneous causes (negative result on conventional automated blood culture), including the following intracellular organisms: parasites (malaria [n =12], babesiosis [n =1]); bacteria (scrub typhus [n =5]); viruses (Epstein–Barr [n =1], cytomegalovirus [n =1]); and unidentified pathogen[s] (n =7). Splenomegaly was more common among patients with miscellaneous systemic infection; infarction involving other organs was rare. Thirty-eight patients had localized infections (e.g., respiratory, intra-abdominal, or skin and soft tissue infection), and most (35 of 38) had other risk factors for SI. ConclusionsIn this study, various infectious conditions were found to be associated with SI, and intracellular organisms were the most common causative pathogens. Further studies are needed to examine other possible etiologies and the underlying pathophysiological mechanisms.

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“…In this study, 27 patients (26.7%) were classi ed as having miscellaneous systemic infections; the causative pathogens in most of these cases were intracellular organisms. Malaria and babesiosis have previously been shown to cause SI [17,18]. Both are parasitic diseases in which the parasites infect the red blood cells (RBCs).…”

Section: Discussionmentioning

confidence: 99%

Splenic Infarction and Infectious Diseases in Korea

Chung²,

Lee

et al. 2020

Preprint

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Background Although the etiology of splenic infarction (SI) is multi-factorial, the nature of its relationship with infectious diseases is not well understood. We thus aimed to investigate the relationship between SI and infection using a retrospective approach. Methods We reviewed the hospital records of patients with SI who visited Inha University Hospital (Incheon, Republic of Korea) between January 2008 and December 2018. We collected and analyzed data on the patients’ clinical presentation, causative pathogens, risk factors, and radiologic findings. Results Of the 353 patients with SI, 101 patients with infectious conditions were enrolled in the study and their data were analyzed to identify an association between SI and infection. Ten patients were diagnosed as having infective endocarditis (IE), and 26 patients had bacteremia without IE. Twenty-seven patients had systemic infection due to miscellaneous causes (negative result on conventional automatic blood culture), such as the following intracellular organisms: parasites (12 cases of malaria and 1 case of babesiosis), bacteria (five cases of scrub typhus), viruses (one case each of Epstein–Barr virus infection and cytomegalovirus infection) or not identified pathogen (seven cases). Splenomegaly was more common among patients with miscellaneous systemic infection, and infarction involving other organs was rare. Twenty-one patients had localized infections (e.g. respiratory, intra-abdominal, or skin and soft tissue infection), and most of them (18 of 21) had other risk factors of SI. Conclusions In this study, various infectious conditions were found to be associated with SI, and intracellular organisms were the most common pathogens observed. Further studies are needed to examine other possible etiologies and the underlying pathophysiologic mechanisms.

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Splenic infarction and malaria

Abstract: Identification of infarction may allow specific recommendations for management, and associated complications such as splenic rupture should be excluded. Outcome is generally favourable and conservative management is the preferred option.

Cited by 13 publications

References 17 publications

Splenic Infarct Secondary to High Altitude Exposure in Sickle Cell Trait Patients: A Case Series

Splenic Infarct Secondary to High Altitude Exposure in Sickle Cell Trait Patients: A Case Series

Splenic Infarction and Infectious Diseases in Korea

Splenic Infarction and Infectious Diseases in Korea

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