Splenic metastases from cervical carcinoma: a case report

Abstract

Splenic metastasis from squamous cell carcinoma of the uterine cervix is an unusual event in the natural history of the disease. The authors report one such uncommon occurrence in a 41-year-old female who presented initially with cervical carcinoma (stage IIB) and was treated with radical radiotherapy with concurrent weekly chemotherapy. Following a disease-free interval of less than a year, she developed hepatosplenic metastases despite being locally controlled. The literature relevant to the report is also discussed. This report reaffirms the notion that splenic metastases from cervical carcinoma are rare events but can occur as part of widespread dissemination.

Splenic Metastasis from Cancer of Uterine Cervix—a Rare Case

“…Solitary splenic metastasis from squamous cell carcinoma of uterine cervix was first reported by Brufman et al in 1977 [15]. As per our knowledge, 11 cases of squamous cell carcinoma metastatic to spleen without evidence of disseminated disease have been reported [9,[15][16][17][18][19][20][21][22][23][24]. Our case is possibly the 12th reported case.…”

Splenic metastasis from cervical cancer: Case report and review of the literature

“…We reviewed the literature searching the terms ‘spleen metastasis’, ‘splenic metastases’ and ‘cervical cancer’ or ‘cancer of cervix’ and we found only eight cases reported (Table 1). 4–11 Treatment of such recurrences consisted of surgery plus chemotherapy in three cases, surgery alone in one case and chemotherapy alone in four cases.…”

“…However in case of metastatic tumor of the spleen with widespread visceral dissemination of primary cervical cancer, surgery has limited indications because the overall prognosis of this advanced disease is poor, and no data exist on survival. In cases of symptomatic splenomegaly, splenectomy can be performed as palliative intent with acceptable morbidity to improve the quality of life 5–7,11 . Indeed it is difficult to predict the prognostic impact of a solitary splenic metastasis surgically treated, because of the rarity of this lesion and the heterogeneity of literature data that only concern single case reports with short follow‐up periods 4–11 .…”

“…The most common sites of distant relapse include the aortic and mediastinal nodes, lungs and skeleton 3 . To our knowledge only a few cases of splenic recurrences from cervical cancer have been described in the literature 4–11 . In this paper we report a case of splenic cervical cancer metastasis treated with surgery.…”

Isolated splenic metastasis from a thymic carcinoma: A case report

“…Rare metastatic sites reported are kidney, prostate, skin, endometrium. 15 Most patients with splenic involvement usually present with multi-visceral disseminated diseases. Isolated splenic metastasis is exceedingly rare.…”