“…When splenic masses and nodules are detected; hemangioma, hamartoma, inflammatory pseudotumor, non-Hodgkin lymphoma and Hodgkin's disease; granulomatous diseases such as sarcoidosis, tuberculosis and histoplasmosis, should be considered in differential diagnosis along with metastasis. It is well known that the spleen is much more protected against metastases due to anatomical, physiological and lymphoid features compared to the organs [9,10]. Splenic capsule, constant blood flow, rhythmic contractility, sharpspins of the spleen artery, high immune cell count and high angiogenesis inhibitory factor levels complicate tumor embolism to reach the spleen [11].…”