Splenic micronodular T-cell/histiocyte-rich large B-cell lymphoma

Kan, Elena; Levy, Itai; Benharroch, Daniel

doi:10.1016/j.anndiagpath.2006.12.006

Cited by 7 publications

(15 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is possible that in several of the 40 or so cases of SMTHLBCL that have been identified to date, prior corticosteroid treatment was administered but unreported [10]. This may have contributed to the complexity of the diagnostic approach.…”

Section: Discussionmentioning

confidence: 79%

“…Involvement of the spleen by a Tcell lymphoma is usually marked by extensive necrosis and an admixture of lymphoid cells of all sizes. Nodular lymphocyte predominant Hodgkin lymphoma rarely presents with isolated involvement of the spleen [1,10].…”

Section: Discussionmentioning

confidence: 99%

“…Follicular lymphoma has rarely involved the spleen in the absence of nodal disease. Moreover, bone marrow involvement by SMTHLBCL has been diagnosed before as follicular lymphoma [10].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Splenic micronodular T-cell/histiocyte-rich large B-cell lymphoma: effect of prior corticosteroid therapy

2009

Self Cite

View full text Add to dashboard Cite

We report on three patients who were treated with corticosteroids only prior to the diagnosis of splenic lymphoma. Corticosteroids were administered for different conditions, at different doses, and for various periods of time. The primary diagnosis was splenic micronodular T-cell/histiocyte-rich large B-cell lymphoma in the three cases, and it was reached with variable difficulty. We suggest that the corticosteroid treatment was one of the causes for the complications in reaching a diagnosis. The morphologic appearance of the microscopic splenic nodules was the most variable feature and may possibly reflect the dose and duration of the corticosteroid therapy. However, the histopathologic changes are probably not related with Epstein-Barr virus-induced immunosuppression.

show abstract

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Splenic micronodular T-cell/histiocyte-rich large B-cell lymphoma: effect of prior corticosteroid therapy

2009

Self Cite

View full text Add to dashboard Cite

show abstract

“…The review is based primarily on three articles on MTLBL published by our group between 2008 and 2011 [8][9][10], since the results and conclusions thereof had not been interpreted to our complete satisfaction. Differences noted between MTLBL and THRLBCL had not been investigated in an exhaustive manner [1].…”

Section: Methodsmentioning

confidence: 99%

“…In 2008, Kan et al, reported on a 63-year-old woman who complained of fatigue, fever, and weight loss [8]. Blood exams revealed anemia, hypo-γ-globulinemia and elevated LDH.…”

Section: Unfolding the Storymentioning

confidence: 99%

Splenic Micronodular T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: The Corticosteroid Pretreatment Hypothesis

Samueli¹,

Nalbandyan²,

Benharroch³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Splenic micronodular T-cell/histiocyte-rich large B-cell lymphoma is possibly derived from nodal T-cell/histiocyte-rich large B-cell lymphoma; however, a transition between the nodal and splenic micronodular forms has not been described to date. Of note, the only lymph nodes to be involved in association with the splenic micronodular pattern of the disease are the splenic hilar lymph nodes, and that, with partial involvement only. Kan et al, in their series of articles, have raised the possibility that corticosteroids, when prescribed prior to splenectomy, cause histopathological and functional modulations (apoptosis, necrosis, tissue shrinkage), which modify or even obscure the diagnostic morphological features. The indications for glucocorticoid therapy are either related to the suspected lymphoma, or else to other comorbidities, like asthma and autoimmune disorders. We propose that patients with the splenic, rather than nodal subset of the disease are likely to have been prescribed corticosteroids prior to histopathologic examination of the involved tissue, causing disparate morphologies in the spleen. Apoptosis, as induced by corticosteroids, is hypothesized as the major mechanism initiating the histopa-thological and functional changes in the splenic micronodular variant of our patients.

show abstract

Lymphomas of the Spleen

Sohani¹,

Zukerberg²

2011

Extranodal Lymphomas

View full text Add to dashboard Cite

Splenic micronodular T-cell/histiocyte-rich large B-cell lymphoma

Cited by 7 publications

References 7 publications

Splenic micronodular T-cell/histiocyte-rich large B-cell lymphoma: effect of prior corticosteroid therapy

Splenic micronodular T-cell/histiocyte-rich large B-cell lymphoma: effect of prior corticosteroid therapy

Splenic Micronodular T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: The Corticosteroid Pretreatment Hypothesis

Lymphomas of the Spleen

Contact Info

Product

Resources

About