Splenic Resection or Heterotopic Transplantation of Splenic Tissue as Alternatives to Splenectomy

Alwmark, A; Bengmark, S; Gullstrand, Per; Idvall, Ingrid; Schalén, Claës

doi:10.1159/000128356

Cited by 12 publications

(2 citation statements)

References 14 publications

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“…The previous experiments on the ability of autotransplanted splenic tissue to resist intravenous bacterial challenge had been done 10-18 weeks after reimplantation [7,9]. In the present study, the duration of the autotransplanted splenic tissue in experimental animals has been increased to 30 weeks.…”

mentioning

confidence: 90%

Regeneration and function of autotransplantation of splenic tissue after splenectomy

et al. 1986

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In traumatic rupture, it is often not possible to repair the spleen. Splenectomy results in increased susceptibility to sepsis with a high mortality rate. Autotransplantation of splenic tissue has been suggested, but its functional value is still in doubt, particularly the ability of autotransplanted spleen to resist intravenous bacterial challenge. The ability to sequestrate denatured 99roTe (technetium-99m) RBC (red blood cells) and to resist intravenous pneumococci was studied in sham-operated (control) rats, splenectomized rats, and splenectomized rats with autotransplanted spleen. Histopathologic tests were also performed. There was a gradual increase in the splenic sequestration of the denatured 99mTc RBC with a spleen-to-blood ratio of 0.19 to 1.5 at 2 and 30 weeks after the splenic reimplantation. Prior to 18 weeks after the splenic autotransplantation, no rat survived the intravenous pneumococcal challenge, but at 28-30 weeks, 80% of the rats survived the challenge indicating an increased splenic activity at this time. There was also a corresponding increase in splenic tissue weight from 241 mg at the time of autotransplantation to 417 mg beginning at the 24th week after the reimplantation. Four to 5 weeks after the transplantation, the spleens had a fairly normal histological architecture. The present study, therefore, indicates that autotransplanted splenic tissue is capable of restoring the ability to resist intravenously injected pneumococcai challenge, to sequestrate denatured 99mTC RBC, and to regenerate normal splenic tissue within 24-30 weeks after the reimplantation.Traumatic rupture of the spleen is a common injury especially in victims of road traffic accidents. Often the injured spleen cannot be repaired and splenec-

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confidence: 90%

Regeneration and function of autotransplantation of splenic tissue after splenectomy

et al. 1986

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“…Εν τω μεταξύ η σπληνεκτομή καθιερώνεται σαν θεραπεία απόλυτης επιλογής στις κακώσεις του σπλήνα καθώς εφαρμόζεται απο μεγάλα ονόματα της χειρουργικής όπως τους Kocher, Moynihan, Wright κ.ά. Παρά τις αμφισβητήσεις για την πλήρη λειτουργικότητα του μεταμοσχευθέντος ιστού, επειδή αυτή σχετίζεται με την ελάχιστη μάζα του εναπομείναντος σπληνικού ιστού (30 -50 gr ή 1/3 του σπλήνα) και την αιματική ροή στο σπληνικό ιστό 5 • 270 , η μέθοδος παρέχει ικανού βαθμού προστασία και σήμερα καθιερώνεται σαν η μέθοδος διατήρησης σπληνι κού ιστού όταν δεν μπορεί να εφαρμοσθεί άλλη μέθοδος.…”

Section: β συρραφή και διάφοροι τρόπο διατήρησηςunclassified

Συμβολη Στην Αντιμετωπιση Των Ρηξεων Του Σπληνα Με Ειδικη Μεθοδο Συρραφης. (Πειραματικη Μελετη Σε Σκυλους)

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Does Survival Depend on the Amount of Autotransplanted Splenic Tissue?

Shokouh-Amiri

Rahimi‐Saber²,

Hansen³

et al. 1990

Arch Surg

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Susceptibility to Streptococcus pneumoniae infection was studied in 11 groups of rats allocated to sham operation, splenectomy, or splenic autotransplantation of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90% of the removed spleen. Three months later, all rats were exposed intravenously to type 1 Streptococcus pneumoniae (median lethal dose, LD50, for control group). Survivors were killed 13 days after the bacterial challenge. Autopsy showed that more splenic tissue was recovered in rats that received less than 50% splenic tissue compared with those that received 50% or more. More survivors were found among sham-operated rats (47.5%; 95% confidence intervals, 32 to 68) and rats that had 40% splenic tissue implanted (35%; confidence interval, 20 to 54) or those that were found to have regenerated 40% splenic tissue. We conclude that 40% of the spleen should be autotransplanted to protect the rat optimally against infection after splenectomy.

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Splenic Resection or Heterotopic Transplantation of Splenic Tissue as Alternatives to Splenectomy

Cited by 12 publications

References 14 publications

Regeneration and function of autotransplantation of splenic tissue after splenectomy

Regeneration and function of autotransplantation of splenic tissue after splenectomy

Συμβολη Στην Αντιμετωπιση Των Ρηξεων Του Σπληνα Με Ειδικη Μεθοδο Συρραφης. (Πειραματικη Μελετη Σε Σκυλους)

Does Survival Depend on the Amount of Autotransplanted Splenic Tissue?

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