Splenius capitis: sensitive target for the cVEMP in older and neurodegenerative patients

Ali, Fatema Mohammed; Westling, Martin; Zhao, Luke Hong Lu; Camp, Aaron J.

doi:10.1007/s00405-019-05582-7

Cited by 10 publications

(7 citation statements)

References 28 publications

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“…Thus, there is a high proportion of false positive observations in the elderly (where a “positive” observation consists of an absent cVEMP). Recent work of ours ( 109 ) has shown that recording cVEMPs from both ipsilateral-SCM and contralateral-SPL in a simple head-turned posture reduces this rate of false positives both in the elderly, and in a cohort of patients with Parkinson's disease (PD). Previously, PD was associated with a low rate of cVEMPs ( 110 ).…”

Section: Distribution Of Descending Commands In the Motor Peripherymentioning

confidence: 99%

Animal Models of Vestibular Evoked Myogenic Potentials: The Past, Present, and Future

Camp

2018

Front. Neurol.

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Vestibular-evoked myogenic potentials (VEMPs) provide a simple and cost-effective means to assess the patency of vestibular reflexes. VEMP testing constitutes a core screening method in a clinical battery that probes vestibular function. The confidence one has in interpreting the results arising from VEMP testing is linked to a fundamental understanding of the underlying functional anatomy and physiology. In this review, we will summarize the key role that studies across a range of animal models have fulfilled in contributing to this understanding, covering key findings regarding the mechanisms of excitation in the sensory periphery, the processing of sensory information in central networks, and the distribution of reflexive output to the motor periphery. Although VEMPs are often touted for their simplicity, work in animals models have emphasized how vestibular reflexes operate within a broader behavioral and functional context, and as such vestibular reflexes are influenced by multisensory integration, governed by task demands, and follow principles of muscle recruitment. We will conclude with considerations of future questions, and the ways in which studies in current and emerging animal models can contribute to further use and refinement of this test for both basic and clinical research purposes.

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Section: Distribution Of Descending Commands In the Motor Peripherymentioning

confidence: 99%

Animal Models of Vestibular Evoked Myogenic Potentials: The Past, Present, and Future

Camp

2018

Front. Neurol.

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“…In our meta-analysis, abnormal VEMP findings were divided into three categories, namely, absent, delayed, and low-amplitude VEMP responses. The complete absence of VEMPs may reflect more severe axonal damage and neurodegeneration [ 24 ]. In our study, we found that the absence rates of VEMPs (cVEMP, oVEMP, and mVEMP) were significantly higher in patients with PD than in healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…There was still evidence that was consistent with previous observations suggesting that the cVEMP P13 latency was significantly increased in patients with PD, whereas no significant differences in N23 latency was found [ 25 ]. There are also some studies suggesting that there are no significant differences in the latency of cVEMP between controls and patients with PD [ 22 , 24 ]. Conversely, the shortening of VEMP latencies was observed in both cVEMP and oVEMP latencies in one article.…”

Section: Discussionmentioning

confidence: 99%

“… ( A ) Meta-analysis of cVEMP P13 latency in patients with PD compared with healthy controls [ 6 , 7 , 8 , 11 , 13 , 14 , 15 , 16 , 17 , 22 , 23 , 24 , 25 , 26 , 27 ]; ( B ) meta-analysis of oVEMP P15 latency in patients with PD compared with healthy controls [ 7 , 8 , 11 , 13 , 14 , 15 , 23 , 26 ]; ( C ) meta-analysis of peak-to-peak amplitude of cVEMP in patients with PD compared with healthy controls [ 8 , 11 , 13 , 15 , 16 , 17 , 23 , 24 , 26 , 27 ]; ( D ) Forest plot of AAR of cVEMP in patients with PD compared with healthy controls [ 7 , 8 , 11 , 23 ]. …”

Section: Figurementioning

confidence: 99%

“… ( A ) Sub-group analysis of peak-to-peak amplitude based on age [ 8 , 11 , 13 , 15 , 16 , 17 , 23 , 24 , 26 , 27 ]; ( B ) sub-group analysis of P15 latency based on age [ 7 , 8 , 11 , 23 ]; ( C ) sub-group analysis of peak-to-peak amplitude based on Hoehn and Yahr stage [ 8 , 11 , 13 , 15 , 23 , 26 , 27 ]. …”

Section: Figurementioning

confidence: 99%

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Assessment of Vestibular-Evoked Myogenic Potentials in Parkinson’s Disease: A Systematic Review and Meta-Analysis

2022

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(1) Background: The brainstem plays an essential role in the early stage of Parkinson’s disease (PD), but it is not widely tested in clinical examinations of PD. Vestibular-evoked myogenic potentials (VEMPs) are recognized as fundamental tools in the assessment of brainstem function. The aim of our meta-analysis was to assess the abnormal findings of VEMPs in patients with PD. (2) Methods: Up to 14 February 2022, PubMed, Embase, and Web of Science were searched to evaluate VEMPs in patients with PD in comparison with respective controls. The study protocol was registered at PROSPERO (CRD42022311103). (3) Results: A total of 15 studies were finally included in our meta-analysis. The absence rates of VEMPs in patients with PD were significantly higher than those of control groups (cVEMP: OR = 6.77; oVEMP: OR = 13.9; mVEMP: OR = 7.52). A delayed P13 latency, a decreased peak-to-peak amplitude, and an increased AAR of cVEMP, and a delayed oVEMP P15 latency were also found in patients with PD. (4) Conclusions: Our meta-analysis indicates abnormal VEMP findings in patients with PD, revealing the dysfunction of the brainstem in PD. VEMP tests, especially cVEMP tests, could be a helpful method for the early detection of PD.

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Static and dynamic otolith reflex function in people with Parkinson’s disease

Hawkins

Chiarovano

Paul

et al. 2020

Eur Arch Otorhinolaryngol

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Splenius capitis: sensitive target for the cVEMP in older and neurodegenerative patients

Cited by 10 publications

References 28 publications

Animal Models of Vestibular Evoked Myogenic Potentials: The Past, Present, and Future

Animal Models of Vestibular Evoked Myogenic Potentials: The Past, Present, and Future

Assessment of Vestibular-Evoked Myogenic Potentials in Parkinson’s Disease: A Systematic Review and Meta-Analysis

Static and dynamic otolith reflex function in people with Parkinson’s disease

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