Splenomegalie mit multiplen unklaren Parenchymläsionen

Abstract

A 53-year-old female patient presented with splenomegaly, uncertain lesions of the spleen, pancytopenia and suspected aortitis. Reduced strength and muscular pain but no B symptoms were also present. Alterations of the spleen had been known for a long time. Blood examination, laboratory tests and magnetic resonance imaging (MRI) confirmed an aortitis. Concerning the splenic changes neither ultrasound nor MRI could provide conclusive or even pathognomonic findings. Because of an existing pancytopenia and diagnostic obscurity, the patient underwent splenectomy. The histological diagnosis was finally concluded as multifocal littoral cell angioma.

Littoral Cell Angioma of the Spleen

“…In case reports cytology was applied as well, e. g., using endoscopic ultrasound [8]. Case reports of littoral cell angioma of the spleen have been published including associations with colorectal [9 -11], pancreatic and hepatocellular adenocarcinoma [7, 11,12], carcinoma of the lung [12], pseudopapillary tumor of the pancreas [13], urogenital malignancies [14], malignant lymphoma [15] including plasmablastic B-cell lymphoma associated with rapidly progressive Bcell dominated inflammatory neuropathy [16], myelodysplastic syndrome [17], angiosarcoma of the spleen in siblings [18], aortitis [19] and other immuno-mediated diseases [20]. Littoral cell angioma of the spleen involving also accessory organs (pancreatic tail) presenting as splenic rupture was observed [21].…”