2011
DOI: 10.4161/viru.2.1.14611
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Splenosis and sepsis: The born-again spleen provides poor protection

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Cited by 37 publications
(45 citation statements)
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“…TS mainly occurs after gunshot wounds or motor vehicle injuries which can explain that most of cases of TS are described in men. [3,4,7,16] Abdominal splenosis is found to be associated in 24% of TS cases. [3] While peritoneal splenosis is frequently symptomatic with abdominal pain, gastrointesinal obstruction, or hydronephrosis, TS has been exceptionally described as the cause of hemoptysis, thoracic pain, or cough.…”
Section: Discussionmentioning
confidence: 99%
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“…TS mainly occurs after gunshot wounds or motor vehicle injuries which can explain that most of cases of TS are described in men. [3,4,7,16] Abdominal splenosis is found to be associated in 24% of TS cases. [3] While peritoneal splenosis is frequently symptomatic with abdominal pain, gastrointesinal obstruction, or hydronephrosis, TS has been exceptionally described as the cause of hemoptysis, thoracic pain, or cough.…”
Section: Discussionmentioning
confidence: 99%
“…The absence of Howel–Jolly bodies or siderocytes in peripheral blood indicates the presence of functional splenic tissue (in patients with splenectomy). [4] Thirty years ago, diagnosis of TS was usually confirmed by studying tissue samples obtained by such invasive measures (thoracotomy, VATS, needle biopsy). [2,3,9] However it is now well-established, that a definitive diagnosis can be reached using non-invasive diagnostic tools such as imaging studies associated with functional study of the uptake of particles or cells: Tc-99 sulfur colloid scintigraphy, Tc-99 sulfur heat-damage erythrocytes scintigraphy, Tc-99 white blood cell scan or indium 111-labeled platelet, or super-paramagnetic iron oxide particles MRI.…”
Section: Discussionmentioning
confidence: 99%
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“…However, while the histology resembles normal splenic tissue, it is still associated with reduced immune function as the residual volume and function is insufficient to confer protection against overwhelming post-splenectomy infection, and therefore, the need for immunisation and early prophylactic penicillin remains. 3 In conclusion, thoracic splenosis should be considered in a patient presenting with asymptomatic left pleural nodules and a remote history of thoracoabdominal trauma, especially in the setting of known splenic injury and diaphragmatic rupture.…”
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confidence: 96%