2024
DOI: 10.1002/adbi.202400006
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Spliceosomal snRNAs, the Essential Players in pre‐mRNA Processing in Eukaryotic Nucleus: From Biogenesis to Functions and Spatiotemporal Characteristics

Yuan Su,
Jiaming Wu,
Wei Chen
et al.

Abstract: Spliceosomal small nuclear RNAs (snRNAs) are a fundamental class of non‐coding small RNAs abundant in the nucleoplasm of eukaryotic cells, playing a crucial role in splicing precursor messenger RNAs (pre‐mRNAs). They are transcribed by DNA‐dependent RNA polymerase II (Pol II) or III (Pol III), and undergo subsequent processing and 3′ end cleavage to become mature snRNAs. Numerous protein factors are involved in the transcription initiation, elongation, termination, splicing, cellular localization, and terminal… Show more

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