2004
DOI: 10.1016/j.bbrc.2004.08.107
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Spliceosome Sm proteins D1, D3, and B/B′ are asymmetrically dimethylated at arginine residues in the nucleus

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Cited by 39 publications
(29 citation statements)
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“…The same phenomenon has been observed with PRMT5 (36). This indicates that the production of ADMA, albeit in small quantities, might be a consistent property of Type II PRMTs.…”
Section: Discussionsupporting
confidence: 63%
“…The same phenomenon has been observed with PRMT5 (36). This indicates that the production of ADMA, albeit in small quantities, might be a consistent property of Type II PRMTs.…”
Section: Discussionsupporting
confidence: 63%
“…In contrast, nuclear PRMT5 is found in association with Groucho (60) and HDAC2/mSin3A/ Brg1 (59) repressor complexes that mediate histone methylation. PRMT5 methylation of the MBD2 repressor inhibits its DNA and HDAC binding (77), whereas methylation of nucleolin and Sm proteins regulates their nuclear localization (52,79). Mutually exclusive recruitment of the cofactors pICln and RioK1 determines PRMT5 substrate specificity (17).…”
Section: Discussionmentioning
confidence: 99%
“…6 Many of these have strong interactions with nucleic acids and are involved in processes such as splicing of premRNA, transcription, protein translation, and signal transduction. [5][6][7][8] Arginine methylation is also involved in targeting proteins for nuclear import. 9 Regulation of methylation by S-adenosylmethionine and S-adenosylhomocysteine All PRMTs use S-adenosylmethionine (SAM), which is synthesized from methionine and ATP, as the methyl group donor.…”
Section: Protein Methylationmentioning
confidence: 99%
“…8,20 It was recently shown that autoantibodies to dsDNA cross-react with the arginine-glycine-rich domain of heterogeneous nuclear ribonucleoprotein A2 (hnRNP A2). 21 In the presence of anti-dsDNA, methylation of hnRNP A2 by PRMT1 was increased in a dose-dependent manner to 3.5 times the control level.…”
Section: Stimulation Of Protein Methylation By Autoantibodiesmentioning
confidence: 99%