The main result of this paper is an explicit description of the representation of the metasymplectic space related to an arbitrary building of mixed type F 4 in 25-dimensional projective space. As an application, we study collineations of such spaces the fixed point structure of which is a Moufang quadrangle. We show that the exceptional Moufang quadrangles of type F 4 can be obtained as the intersection of the mixed metasymplectic space with a Baer subspace of the ambient projective space. We also determine the group of collineations fixing a mixed quadrangle and, more surprisingly, observe that it has infinite order, whereas it was generallly believed to have just order 2. Finally, we classify collineations of the mixed metasymplectic space fixing mixed Moufang quadrangles arising from subspaces.