2019
DOI: 10.1136/jnnp-2019-320534
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Split elbow sign: more evidence for the importance of cortical dysfunction in ALS

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Cited by 11 publications
(4 citation statements)
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“…Although the literature appraising this particular phenomenon is scarce, recent studies emphasised that in upper limbs, the biceps brachii is invariably weaker than of the triceps, irrespective of handedness. [21][22][23] More recently, the presence of the split elbow phenomenon was confirmed in a larger study, although contradictory findings have been reported. 23 24…”
Section: Other Split Phenotypes In the Upper Limbsmentioning
confidence: 90%
“…Although the literature appraising this particular phenomenon is scarce, recent studies emphasised that in upper limbs, the biceps brachii is invariably weaker than of the triceps, irrespective of handedness. [21][22][23] More recently, the presence of the split elbow phenomenon was confirmed in a larger study, although contradictory findings have been reported. 23 24…”
Section: Other Split Phenotypes In the Upper Limbsmentioning
confidence: 90%
“…The observation of dissociated muscle wasting as a specific clinical feature of ALS has further underscored the importance of cortical dysfunction in ALS pathogenesis [18]. The split-hand phenomenon refers to preferential wasting of the thenar group of intrinsic hand muscles, namely abductor pollicis brevis (APB) and first dorsal interosseous (FDI), compared to the hypothenar muscles (Figure 3) [19].…”
Section: Clinical Insightsmentioning
confidence: 99%
“…This split-hand syndrome is believed to result from the associated degeneration of UMNs and LMNs [32]. In addition, other split syndromes such as splithand plus, split-elbow, and split-leg phenomenon have been described in ALS involving upper or lower limbs [33][34][35]. In this regard, a preferential degeneration of the hyoglossus may indicate disproportionate muscle atrophy in the tongue, presumably referred to as the 'split-tongue phenomenon,' which should be further investigated through electrophysiological studies.…”
Section: Plos Onementioning
confidence: 99%