Split liver transplantation: Past, present and future

Abstract

The technique of liver splitting offers an effective way of increasing the donor pool and decreasing pediatric waiting list mortality. A donor liver is divided in such a way that the left lateral liver graft can be transplanted into a small child and the right extended liver graft into an adult. This innovative technique did not harm the adult recipient pool. Because of its technical complexity and the initial poor results after split liver transplantation (SLT) this procedure has slowly gained acceptance in the Transplantation Community after its first introduction in 1988 (4). Small children with end stage liver disease suffered the most from the extreme shortage of cadaveric donor organs due to the difficulty of finding size-matched donors. The successful surgical development of SLT and a better donor and recipient selection have led to a reduction of the pediatric pretransplant mortality to nearly zero and to results comparable with those after whole organ transplantation (WLT). By splitting a donor organ into two 'full' hemi-grafts and providing a small adult ( < 60 kg) or a big child ( > 30 kg) with the full left graft and a medium-sized adult (60-80 kg) with the full right graft, a small-for-size situation for adolescents or adults can be avoided and the total number of available grafts can be increased. It is the goal to provide each recipient with its customized graft in the near future. However, splitting for two adults requires high technical skills and profound knowledge of the anatomic variations and should be performed in centers with large transplantation experience.

Pediatric Liver Transplantation

“…These results may be influenced by the diverse nature of the experience accumulated in these registries. When whole-organ, living-donor, and split-liver recipients were compared directly in experienced centers, there was no difference in patient or graft survival or in biliary or vascular complications [37,[90][91][92]. Transplantation of extremely small recipients (b 5 kg) with monosegments has been successful in 27 reported cases, with 85% survival at a mean follow-up of 21 months [93].…”

Extended-criteria donors in liver transplantation Part II: reviewing the impact of extended-criteria donors on the complications and outcomes of liver transplantation

“…Split-liver transplantation (SLT), a technique that allows for the use of two liver grafts from one donor liver, is a good alternative to increasing the donor pool. Conventional splitting along the falciform ligament increases the number of left lateral segment grafts, shortens the pediatric waiting list and reduces the pre-transplant mortality of children [75,76] …”

Diaphragmatic Hernia Resulting in Enterothorax Following Pediatric Liver Transplantation: A Rare Complication

“…At our center, the split liver technique is used in most pediatric transplant recipients (11). The technique of liver splitting offers an effective way of increasing the donor pool and decreasing pediatric waiting list mortality.…”