SpO2/FiO2 Ratio as an Oxygenation Parameter in Pediatric Acute Respiratory Distress Syndrome

Auliawati, Dinna; Suparyatha, Ida Bagus Gede; Wati, Dyah Kanya; Hartawan, I Nyoman Budi; Subanada, Ida Bagus

doi:10.15562/bmj.v5i2.338

Cited by 5 publications

(2 citation statements)

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“…ARDS is a major contributor to morbidity and mortality among children admitted to PICU. It has sophisticated diagnostic criteria that require an invasive blood gas analysis [ 2 , 11 , 12 ]. Concerns about anemia as a result of repeated blood drawing, as well as a desire to use less incursive methods, have led to fewer blood gas tests in critically ill patients.…”

Section: Discussionmentioning

confidence: 99%

“…Acute respiratory distress syndrome (ARDS) is the most frequent clinical condition causing significant morbidity and mortality among children, especially, in the world's poorest countries [ 1 ]. In children, the incidence of ARDS is estimated to be 2.2 to 12.8 per 100,000 patients annually and 2.2% to 2.6% require pediatric intensive care unit (PICU) admission [ 2 ]. A recent report, including 145 worldwide ICUs from 27 countries, showed pediatric acute respiratory distress syndrome (pARDS) affected nearly 3% of PICU patients and 6% required mechanical ventilation [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

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Correlation Between the Ratio of Oxygen Saturation to Fraction of Inspired Oxygen and the Ratio of Partial Pressure of Oxygen to Fraction of Inspired Oxygen in Detection and Risk Stratification of Pediatric Acute Respiratory Distress Syndrome

Lohano

Baloch

Gowa

et al. 2021

Cureus

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Objective: To measure the correlation between the ratio of oxygen saturation to fraction of inspired oxygen [SpO 2 /FiO 2 (SF)] and the ratio of partial pressure of oxygen to fraction of inspired oxygen [PaO 2 /FiO 2 (PF)] among children diagnosed with acute respiratory distress syndrome (ARDS). Methodology: A cross-sectional study was conducted at the pediatric intensive care unit (PICU), National Institute of Child Health (NICH), Karachi, a tertiary care government hospital, from November 2020 to July 2021. One hundred twenty children (of either gender) having the age range of 2 months to 16 years, admitted to PICU with acute onset of respiratory distress, were included in the study. We measured SpO 2 , PaO 2 , FiO 2 and calculated SF and PF ratios. SPSS (version 23) (Armonk, NY: IBM Corp) was used to analyze data, and the Spearmen's correlation test was applied to measure the relationship between SF and PF ratios.Results: A total of 120 children were included, the mean age was 40.58±38.88 months and 67 (55.8%) were males. The mean FiO 2 was 76.33%, the mean PaO 2 and SpO 2 were 100.35 mmHg and 94.37%, respectively.The mean PF ratio was 156.34, and the mean SF ratio was 156.45. There was a strong correlation between the SF ratio and the PF ratio (r=0.688; p=0.001). Conclusion:This study has shown that there is a strong correlation between the SF and PF ratios, and a statistically substantial agreement has been observed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlation Between the Ratio of Oxygen Saturation to Fraction of Inspired Oxygen and the Ratio of Partial Pressure of Oxygen to Fraction of Inspired Oxygen in Detection and Risk Stratification of Pediatric Acute Respiratory Distress Syndrome

Lohano

Baloch

Gowa

et al. 2021

Cureus

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Effect of prone position on respiratory parameters, intubation and death rate in COVID-19 patients: systematic review and meta-analysis

Aeen

Pakzad

Rad

et al. 2021

Sci Rep

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Prone position (PP) is known to improve oxygenation and reduce mortality in COVID-19 patients. This systematic review and meta-analysis aimed to determine the effects of PP on respiratory parameters and outcomes. PubMed, EMBASE, ProQuest, SCOPUS, Web of Sciences, Cochrane library, and Google Scholar were searched up to 1st January 2021. Twenty-eight studies were included. The Cochran's Q-test and I2 statistic were assessed heterogeneity, the random-effects model was estimated the pooled mean difference (PMD), and a meta-regression method has utilized the factors affecting heterogeneity between studies. PMD with 95% confidence interval (CI) of PaO2/FIO2 Ratio in before–after design, quasi-experimental design and in overall was 55.74, 56.38, and 56.20 mmHg. These values for Spo2 (Sao2) were 3.38, 17.03, and 7.58. PP in COVID-19 patients lead to significantly decrease of the Paco2 (PMD: − 8.69; 95% CI − 14.69 to − 2.69 mmHg) but significantly increase the PaO2 (PMD: 37.74; 95% CI 7.16–68.33 mmHg). PP has no significant effect on the respiratory rate. Based on meta-regression, the study design has a significant effect on the heterogeneity of Spo2 (Sao2) (Coefficient: 12.80; p < 0.001). No significant associations were observed for other respiratory parameters with sample size and study design. The pooled estimate for death rate and intubation rates were 19.03 (8.19–32.61) and 30.68 (21.39–40.75). The prone positioning was associated with improved oxygenation parameters and reduced mortality and intubation rate in COVID-19 related respiratory failure.

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Oxygenation saturation index in neonatal hypoxemic respiratory failure

Tsurukawa,

Zuiki,

Naito

et al. 2024

Pediatrics International

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BackgroundThis study aimed to assess the validity of the oxygenation saturation index (OSI) and the ratio of oxygen saturation to the fraction of inspired oxygen (FIO2) (S/F ratio) with percutaneous oxygen saturation (OSISpO2 and the Sp/F ratio) and to evaluate the correlation between these values and the oxygen index (OI). It also determined their cut‐off values for predicting OI in accordance with neonatal hypoxic respiratory failure severity.MethodsWe reviewed the data of 77 neonates (gestational age 31.7 ± 6.1 weeks; birthweight, 1768 ± 983 g) requiring invasive mechanical ventilation between 2013 and 2020, 1233 arterial blood gas samples in total. We calculated the OI, OSISpO2, OSI with arterial oxygen saturation (SaO2) (OSISaO2), Sp/F ratio, and the ratio of SaO2 to FIO2 (Sa/F ratio).ResultsThe regression and Bland–Altman analysis showed good agreement between OSISpO2 or the Sp/F ratio and OSISaO2 or the Sa/F ratio. Although a significant positive correlation was found between OSISpO2 and OI, OSISpO2 was overestimated in SpO2 > 98% with a higher slope of the fitted regression line than that below 98% of SpO2. Furthermore, receiver‐operating characteristic curve analysis using only SpO2 ≤ 98% samples showed that the optimal cut‐off points of OSISpO2 and the Sp/F ratio for predicting OI were: OI 5, 3.0 and 332; OI 10, 5.3 and 231; OI 15, 7.7 and 108; OI 20, 11.0 and 149; and OI 25, 17.1 and 103, respectively.ConclusionThe cut‐off OSISpO2 and Sp/F ratio values could allow continuous monitoring for oxygenation changes in neonates with the potential for wider clinical applications.

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SpO2/FiO2 Ratio as an Oxygenation Parameter in Pediatric Acute Respiratory Distress Syndrome

Cited by 5 publications

References 0 publications

Correlation Between the Ratio of Oxygen Saturation to Fraction of Inspired Oxygen and the Ratio of Partial Pressure of Oxygen to Fraction of Inspired Oxygen in Detection and Risk Stratification of Pediatric Acute Respiratory Distress Syndrome

Correlation Between the Ratio of Oxygen Saturation to Fraction of Inspired Oxygen and the Ratio of Partial Pressure of Oxygen to Fraction of Inspired Oxygen in Detection and Risk Stratification of Pediatric Acute Respiratory Distress Syndrome

Effect of prone position on respiratory parameters, intubation and death rate in COVID-19 patients: systematic review and meta-analysis

Oxygenation saturation index in neonatal hypoxemic respiratory failure

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