Spoligotypes of Mycobacterium tuberculosis complex isolates from patients residents of 11 states of Brazil

Genetic diversity of the Mycobacterium tuberculosis Beijing family in Brazil and Mozambique and relation with infectivity and induction of necrosis in THP-1 cells

“…Despite the occurrence of MtbB being sporadic in Brazil [15], no data on genetic characterization of such isolates are available. In addition, it is a challenge to determine why this family is not successful in Brazil, a country with predominance of the Latin American Mediterreanean (LAM) lineages [29].…”

Mycobacterium tuberculosis of the RD Rio Genotype Is the Predominant Cause of Tuberculosis and Associated with Multidrug Resistance in Porto Alegre City, South Brazil

“…An additional reason for studying the features of the spoligofamilies was the recent discovery of RD Rio , a subfamily inside the larger LAM spoligofamily, which seems to be prevalent in several places in Brazil (18)(19)(20)(21)(22)(23) but also in many other countries, particularly in Central and South America, Europe, and Africa (19 (24) as well as with drug resistance (24). To confirm and expand these findings, the present study was undertaken in Rio Grande do Sul (RS), the southernmost Brazilian state, for which no data on RD Rio status and characteristics exist.…”

Presencia del genotipo Beijing entre cepas del complejo Mycobacterium tuberculosis en dos centros de salud de la Región Metropolitana-Chile

“…Se describe además el genotipo Beijing y se demuestra la predominancia del genotipo LAM y T. Estudios latinoamericanos más extensos realizados en Brasil, Argentina, Venezuela, Paraguay, Perú, Guayana-Francesa y Colombia muestran una clara predominancia del genotipo LAM en relación a los genotipos T y Haarlem 1,6,[22][23][24][25][26][27] .…”

“…# El SIT para cada perfil fue obtenido en ambas bases de datos (MIRU-VNTRplus y SITVITWEB). Finalmente, es llamativo que 14% de las cepas estudiadas correspondieron a cepas no previamente clasificadas (cepas huérfanas), siendo esta proporción solamente superada por estudios realizados en Brasil 22 . Será de interés en estudios futuros con un mayor número de cepas corroborar si se mantiene esta proporción y determinar si alguna de estas pudiese corresponder a un clon "chileno" no previamente descrito.…”