Spondyloarthritis Research Consortium of Canada (<scp>SPARCC</scp>) enthesitis index in turkish patients with ankylosing spondylitis: Relationship with disease activity and quality of life

Zahiroğlu, Yeliz; Ulus, Yasemin; Akyol, Yeşim; Tander, Berna; Durmuş, Dilek; Bilgici, Ayhan; Kuru, Ömer

doi:10.1111/1756-185x.12067

Cited by 10 publications

(5 citation statements)

References 33 publications

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“…However, in our early axial SpA cohort, the main peripheral manifestation associated with disability was enthesitis (the association with peripheral arthritis was only significant in the univariable models). The association between disability and enthesitis had previously been described in patients with AS but not in early axial SpA (31,32). Both TNFi and NSAID treatment emerged as third-level predictors of disability in the decision tree model, but not treatment with cDMARDs.…”

Section: Discussionsupporting

confidence: 91%

Long‐Term Association Between Disease Activity and Disability in Early Axial Spondyloarthritis: Results From a Prospective Observational Study of Inflammatory Back Pain

Carvalho

Ruyssen‐Witrand

Marreiros

et al. 2022

Arthritis Care & Research

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Objective Our primary objective was to study the long‐term association between disease activity and disability in axial spondyloarthritis (SpA). Our secondary objective was to define patient profiles according to their level of disability. Methods We analyzed data collected during the first 5 years of follow‐up of a large early axial SpA cohort, the Devenir des Spondylarthropathies Indifferénciées Récentes (DESIR) cohort. Multivariable models were built to study the association between the Health Assessment Questionnaire for Ankylosing Spondylitis (HAQ‐AS) and the Ankylosing Spondylitis Disease Activity Score with C‐reactive protein (ASDAS‐CRP), adjusting for potential confounders. Hierarchical multivariable analysis was conducted using the chi‐square automatic interaction detector (CHAID) method, to help determine how variables best cluster to explain HAQ‐AS. Results Data from 644 patients and 5,152 visits were analyzed. HAQ‐AS was longitudinally, independently, and positively associated with ASDAS‐CRP (adjusted B [adjB] 0.205 [95% confidence interval (95% CI) 0.187, 0.222]), the enthesitis score (adjB 0.011 [95% CI 0.008, 0.015]), the Bath Ankylosing Spondylitis Metrology Index (adjB 0.087 [95% CI 0.069, 0.105]), and female sex (adjB 0.172 [95% CI 0.120, 0.225]). The CHAID decision tree revealed ASDAS‐CRP as the first variable with discriminative power on HAQ‐AS. The cutoffs that separated different patient disability profiles were obtained. Conclusion Disease activity contributes longitudinally to disability and is hierarchically superior to any other variable in explaining this health domain. Enthesitis and spinal mobility are also key drivers of disability in early axial SpA. ASDAS‐CRP cutoffs that separated different patient disability profiles largely mimicked the cutoffs previously defined for ASDAS‐CRP disease activity states.

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Section: Discussionsupporting

confidence: 91%

Long‐Term Association Between Disease Activity and Disability in Early Axial Spondyloarthritis: Results From a Prospective Observational Study of Inflammatory Back Pain

Carvalho

Ruyssen‐Witrand

Marreiros

et al. 2022

Arthritis Care & Research

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“…The patients in these studies had increased pain compared with the other subtypes of juvenile idiopathic arthritis. Given the fact that pain is an important component of the quality of life, it is not surprising that these 2 ERA studies, as well as others, showed worse quality of life in patients with enthesitis compared with patients who did not have it .…”

Section: Discussionmentioning

confidence: 91%

“…In SpA patients with enthesitis, a significantly higher frequency of tender and swollen joint counts as well as more inflammatory axial symptoms have been found . Studies in ankylosing spondylitis (AS) patients revealed a correlation between enthesitis and higher disease activity (measured by the Bath Ankylosing Spondylitis Disease Activity Index [BASDAI]) .…”

Section: Discussionmentioning

confidence: 99%

Clinical Enthesitis in a Prospective Longitudinal Psoriatic Arthritis Cohort: Incidence, Prevalence, Characteristics, and Outcome

Polachek

Chandran

et al. 2017

Arthritis Care & Research

130

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“…The presence of swollen and/or tender joints was investigated with detailed history and physical examination, and patients with arthritis were excluded from the study. Patients and HCs were evaluated by the Spondyloarthritis Research Consortium of Canada (SPARCC), and enthesis points with tenderness were determined and recorded for each participant 21 . US was performed on selected enthesis areas in both groups.…”

Section: Methodsmentioning

confidence: 99%

Detection of subclinical enthesitis by ultrasonography in patients with psoriasis and controls

Karamanlioglu,

Ozkan,

Emel Ceren Arıkan

et al. 2024

ARP Rheumatol

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Introduction: Psoriasis is a widespread chronic inflammatory skin disease; enthesitis is inflammation of the tendon, ligament, and joint capsule insertion, prevalent in patients with psoriatic arthritis. Objectives: The aim of study to evaluate the utility of the Madrid Sonography Enthesitis Index scoring system for accurate detection of subclinical enthesitis in patients with Psoriasis compared with healthy controls. Another objective was to assess increase in enthesis area and Psoriatic arthritis incidence, in a prospective 1-year follow-up. Method: Patients aged ≥18 years who were diagnosed with Psoriasis, without musculoskeletal complaints, and who did not have any clinical sign and/or symptom of enthesitis and synovitis were included in the study. The patients and healthy controls were evaluated with ultrasonography. Ultrasonography evaluation consisted of the detection of gray-scale enthesitis and power Doppler signal in the enthesis areas. The Madrid Sonography Enthesitis Index scoring system was used to quantify the extent of the sonographic enthesis abnormalities. Results: The mean MASEI score, structure, thickness, erosion, and calcification were significantly higher in the Psoriasis group than in the control group. The mean MASEI score, structure, erosion, and calcification measurements were significantly higher at the last examination when compared to the first examination. The triceps was the most commonly affected tendon in both groups. Conclusion: Ultrasonography is an important tool for diagnosis and follow-up of subclinical enthesitis in patients with psoriasis. Regardless of disease duration and severity, patients should be screened using ultrasonography at yearly intervals.

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Spondyloarthritis Research Consortium of Canada (SPARCC) enthesitis index in turkish patients with ankylosing spondylitis: Relationship with disease activity and quality of life

Abstract: The clinical assessment of enthesitis in AS is an important outcome measure, and enthesitis indexes such as SPARCC enthesitis index can be valuable tools in the evaluation of disease activity in AS patients not receiving anti-TNF therapy.

Cited by 10 publications

References 33 publications

Long‐Term Association Between Disease Activity and Disability in Early Axial Spondyloarthritis: Results From a Prospective Observational Study of Inflammatory Back Pain

Long‐Term Association Between Disease Activity and Disability in Early Axial Spondyloarthritis: Results From a Prospective Observational Study of Inflammatory Back Pain

Clinical Enthesitis in a Prospective Longitudinal Psoriatic Arthritis Cohort: Incidence, Prevalence, Characteristics, and Outcome

Detection of subclinical enthesitis by ultrasonography in patients with psoriasis and controls

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