“…micra as a pathogen in spondylodiscitis might be underestimated due to the difficulty of culturing this anaerobic organism. 3 In case 3, the diagnosis of spondylodiscitis caused by P. micra was possible only by 16S rRNA, and culture was negative for P. micra. The reason for the negative culture results might have been previous exposure to antibiotics and/or inappropriate handling of the specimen.…”
Section: Discussionmentioning
confidence: 97%
“…The search revealed only five cases of spondylodiscitis caused by GPAC reported since 1980, including two cases of P. micra (under its former classification Peptostreptococcus micros), one case of Peptoniphilus asaccharolyticus, one case of Finegoldia magna, and one undetected case. 3 A brief summary of the two cases of spondylodiscitis due to P. micra reported previously (cases 1 and 2) and our two cases (cases 3 and 4) is given below; a clinical summary of these four cases is given in Table 1.…”
Section: Methodsmentioning
confidence: 94%
“…2 Although P. micra has been implicated in infections outside the oral cavity, 2 to our knowledge, few cases of P. micra spondylodiscitis have been reported. 3 Here we describe the diagnosis and successful treatment of two cases of spondylodiscitis caused by P. micra after detection using a relatively novel method, and compare these two cases with those described previously.…”
Spondylodiscitis caused by Parvimonas micra, a rarely reported infection, might be under-detected using conventional methods. This report of the detection and treatment of two cases of spondylodiscitis due to P. micra and review of the literature indicates that the use of gene sequencing methods might improve the accuracy of diagnosing this infection.
“…micra as a pathogen in spondylodiscitis might be underestimated due to the difficulty of culturing this anaerobic organism. 3 In case 3, the diagnosis of spondylodiscitis caused by P. micra was possible only by 16S rRNA, and culture was negative for P. micra. The reason for the negative culture results might have been previous exposure to antibiotics and/or inappropriate handling of the specimen.…”
Section: Discussionmentioning
confidence: 97%
“…The search revealed only five cases of spondylodiscitis caused by GPAC reported since 1980, including two cases of P. micra (under its former classification Peptostreptococcus micros), one case of Peptoniphilus asaccharolyticus, one case of Finegoldia magna, and one undetected case. 3 A brief summary of the two cases of spondylodiscitis due to P. micra reported previously (cases 1 and 2) and our two cases (cases 3 and 4) is given below; a clinical summary of these four cases is given in Table 1.…”
Section: Methodsmentioning
confidence: 94%
“…2 Although P. micra has been implicated in infections outside the oral cavity, 2 to our knowledge, few cases of P. micra spondylodiscitis have been reported. 3 Here we describe the diagnosis and successful treatment of two cases of spondylodiscitis caused by P. micra after detection using a relatively novel method, and compare these two cases with those described previously.…”
Spondylodiscitis caused by Parvimonas micra, a rarely reported infection, might be under-detected using conventional methods. This report of the detection and treatment of two cases of spondylodiscitis due to P. micra and review of the literature indicates that the use of gene sequencing methods might improve the accuracy of diagnosing this infection.
“…The etanercept maintained the patient’s liver enzyme levels within the normal range and controlled the arthritis during follow-up of 30 months, in contrast to the infliximab
[13]. Another two cases have been reported where the patients were treated with etanercept and MTX 4mg/week, obtaining a significant improvement in disease activity and liver function, maintained one year after starting etanercept
[14,15]. …”
IntroductionPrimary biliary cirrhosis is an autoimmune disease that tends to progress to fibrosis and cirrhosis with hepatic failure. Primary biliary cirrhosis is often associated with other non- hepatic autoimmune diseases. An association with rheumatoid arthritis has been suggested to coexist in 1.8% to 5.6% of patients with primary biliary cirrhosis, but data supporting this association are scarce. The etiologic and pathogenetic mechanisms are not yet fully understood and several factors have been implicated. The therapeutic management must consider the two pathologies.Case presentationWe describe the case of a 60-year-old Moroccan woman with severe erosive rheumatoid arthritis and primary biliary cirrhosis treated with rituximab. During treatment, we observed a good clinical and biological response of her rheumatoid arthritis but persistent abnormal liver function tests.ConclusionB cells seem to play a major role in the pathogenesis of both rheumatoid arthritis and primary biliary cirrhosis. Additional studies are necessary to better determine the therapeutic role of rituximab in both diseases.
“…The specific microorganism, which causes the vast majority of disc space infections during open or percutaneous procedures, is Staphylococcus aureus [1,2,4]. However, Staphylococcus epidermidis, Pseudomonas aeruginosa, pneumococcus, Brucella and Escherichia coli are also commonly isolated [14][15][16].…”
The antibiotics of cephazolin, ceftazidime, and ceftriaxone had concentration in the NP tissue, which was higher than the stated MIC. Ceftazidime had highest penetration in to NP tissue, and ceftriaxone had the lowest penetration in to NP tissue.
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