Sponge Biopsy in the Diagnosis of Cancer of the Mouth

Gladstone, Sidney A.

doi:10.1097/00006534-195210000-00023

Cited by 2 publications

(2 citation statements)

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“…Therefore, new sampling tools and staining techniques were applied (Table I). [29][30][31][32][33][34][35][36][37][38][39][40][41] Fluorescent DNA-specific dyes, such as acridine orange, have been used to measure the cellular DNA content. 42,43 Image analysis of nucleolar size and diameter as parameters for malignancy was also studied.…”

Section: Conventional Cytologymentioning

confidence: 99%

The role of cytology in oral lesions: A review of recent improvements

Mehrotra

2011

Diagnostic Cytopathology

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Historically, sensitivity and specificity of oral cytology is poor. Using conventional oral cytology for the diagnosis of cancer and its precursors has not had the success that cytologists had hoped for; however, with improved methodology, oral cytology has enjoyed a resurgence of interest. This renewed interest is partly due to the introduction of a specialized brush that collects a full-thickness epithelial sample and not just superficially sloughed cells, as well as analysis of that sample with computer assistance; in addition, a variety of adjunctive techniques have been introduced to potentially enhance the diagnosis of the cytologic specimens including DNA analysis, immunocytochemistry, molecular analysis, and liquid-based preparations. An increase in sensitivity (>96%) and specificity (>90%) of the oral brush biopsy with computer-assisted diagnosis has been reported for identification of malignant and premalignant lesions. Brush cytology is valuable to prevent misdiagnosing doubtful oral lesions, i.e., those lesions without a definitive etiology, diagnosing large lesions where excision of the entire tissue is not possible or practicable, evaluating patients with recurrent malignancies, and monitoring premalignant lesions.

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Section: Conventional Cytologymentioning

confidence: 99%

The role of cytology in oral lesions: A review of recent improvements

Mehrotra

2011

Diagnostic Cytopathology

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“…The aim was to collect a larger amount of cells, to sample a large cellular area and to improve the cell staining. Therefore, new sampling tools, modified object slides or staining dyes were applied (11–16) (Table 2).…”

Section: Historical Developmentmentioning

confidence: 99%

Oral cytology revisited

Mehrotra

Hüllmann

Smeets

et al. 2009

J Oral Pathology Medicine

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During the last decade, oral cytology has once again become the focus of scientific research. This new interest is due to the introduction of a cytobrush for cell collection as well as a computer-assisted analysis (Oral CDx). Although promising, the sensitivity and specificity of conventional oral brush cytology remains limited. To circumvent the problems and improve the accuracy, various adjunctive analytical methods have been attempted. DNA analysis, immunocytochemical and molecular analysis are suggested methodological cytology approaches to improve the validity of oral brush cytology. An increase in sensitivity (up to 100%) and specificity (up to 100%) of oral brush biopsy has been reported on localized pre-malignant and malignant lesions. Oral brush biopsy probably will not replace histopathology in the definitive diagnosis of oral cancer, but it might be valuable for the prevention of misdiagnosis of clinically doubtful oral lesions and for the monitoring of lesions that might proceed on to oral cancer.

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Sponge Biopsy in the Diagnosis of Cancer of the Mouth

Cited by 2 publications

References 0 publications

The role of cytology in oral lesions: A review of recent improvements

The role of cytology in oral lesions: A review of recent improvements

Oral cytology revisited

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