Spongiform central nervous system myelinopathy in african dwarf goats

Polymorphisms of Caprine PrP Gene Detected in Japan

“…The clinical signs of affected goats are slightly different from those of sheep, but the observed variation of incubation period is similar to that described for sheep [11,14]. Studies have shown amino acid polymorphisms of the caprine PrP gene at the following codons: 21 (V→A), 23 (L→P), 49 (G→S), 102 (W→G), 142 (I→M), 143 (H→R), 154 (R→H), 168 (P→Q), 220 (Q→H) and 240 (S→P) [2,3,5,6,11].In Japan, caprine scrapie has not yet been observed, although occurrence of sheep scrapie in Japan has been reported [10,13]. In the present study, we investigated polymorphisms of the PrP gene in goats raised in Japan, to obtain genetic information for use in assessing the risk of the occurrence of scrapie in goats.…”

“…The clinical signs of affected goats are slightly different from those of sheep, but the observed variation of incubation period is similar to that described for sheep [11,14]. Studies have shown amino acid polymorphisms of the caprine PrP gene at the following codons: 21 (V→A), 23 (L→P), 49 (G→S), 102 (W→G), 142 (I→M), 143 (H→R), 154 (R→H), 168 (P→Q), 220 (Q→H) and 240 (S→P) [2,3,5,6,11].…”

“…Three of the amino acid substitutions detected in the present study were novel polymorphisms: at codon 127, a g→a nucleotide substitution in the first codon position caused an amino acid change of G→S; at codon 146, an a→g nucleotide substitution in the second position caused an amino acid change of N→S; at codon 211, a g→a nucleotide substitution caused an amino acid change of R→Q. The remaining 4 amino acid polymorphisms detected in the present study have previously been described: codon 102, W→G; codon 142, I→M; codon 143, H→R; codon 240, S→P [2,5,6,11].…”

Novel polymorphisms in the caprine PrP gene: a codon 142 mutation associated with scrapie incubation period

“…The codon 143 dimorphism was also recently described in African dwarf goats (Obermaier et al, 1995). Despite the fact that individual experiments included only a few carriers for these alleles, all experiments without exception showed that the change from Ile to Met at codon 142 is associated with increased disease incubation periods.…”

Congenital portosystemic shunts and hepatic encephalopathy in goat kids in California

“…29 Spongiform myelinopathy affecting the central nervous system of African Dwarf goats characterized by extensive vacuolation predominantly of the white matter of the diencephalon, mesencephalon, and cerebellar peduncles as well as of the spinal white matter has been reported. 19 The authors suggested a hereditary basis for this disease because all affected dwarf goats from their study were half-brothers or half-sisters, and partly descended from the mating of adult females with the same sire. However, in contrast to the present study, these researchers made the diagnosis of presumptive hereditary primary spongiform encephalomyelopathy as liver lesions were absent in their cases.…”