Spontaneous acromegaly: A retrospective case control study in German shepherd dogs

Fracassi, Federico; Zagnoli, L.; Rosenberg, Dan; Furlanello, Tommaso; Caldín, Marco

doi:10.1016/j.tvjl.2014.06.004

Cited by 9 publications

(9 citation statements)

References 35 publications

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“…In a study on dogs treated with supraphysiological doses of GH, despite an increase in the glomerular filtration rate caused by hypertrophy of the kidney and glomeruli, there was no difference in urinary excretion of phosphate as a result of a concomitant increase in the tubular reabsorption of phosphate (Tryfonidou and others 2003). On the contrary, in a study on dogs with spontaneous acromegaly, a reduction in the urinary excretion of phosphate has been documented (Fracassi and others 2014). Despite the conflicting data, dogs with PDH have low GH plasma concentration compared with control dogs (Corbee and others 2012) and, consequently, GH is unlikely to be directly involved in the decreased urinary fractional excretion of phosphate.…”

Section: Discussionmentioning

confidence: 99%

Urinary excretion of calcium and phosphate in dogs with pituitary‐dependent hypercortisolism: case control study in 499 dogs

et al. 2015

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Pituitary-dependent hypercortisolism (PDH) in dogs is frequently associated with high serum phosphate and parathormone concentrations which are in turn associated with prognosis and clinical presentation. The pathogenesis of such abnormalities remains unknown. The aim of the present study was to evaluate the serum and urinary concentrations and the urinary fractional excretion of phosphate and calcium in dogs with PDH. Medical records of newly diagnosed PDH dogs before treatment from one referral centre were retrospectively evaluated. One clinically normal and one sick dog for each dog with PDH were included as controls. One hundred and sixty-seven dogs with PDH were included. The serum phosphate concentration in PDH dogs was significantly (P<0.0001) higher compared with clinically normal control dogs (CNDs) and sick control dogs (SCDs). The serum calcium concentration in PDH dogs was significantly higher compared with SCDs but not different compared with CNDs. Urinary fractional excretion of phosphate in PDH dogs was significantly lower compared with CNDs and SCDs. Urinary fractional excretion of calcium in PDH dogs was significantly higher compared with CNDs and SCDs. In conclusion, PDH dogs have lower phosphaturia and higher calciuria compared with control dogs. These findings suggest that, at least in part, high serum phosphate concentrations are related to the renal retention of phosphate.

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Section: Discussionmentioning

confidence: 99%

Urinary excretion of calcium and phosphate in dogs with pituitary‐dependent hypercortisolism: case control study in 499 dogs

et al. 2015

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“…4,6 Of note, mammary GH may not only originate from normal mammary tissue, but also from mammary tumors with the potential consequence of acromegaly. 9,19 Acromegaly due to a GH-producing pituitary tumor is extremely rare in dogs. So far, this entity has only been described in three dogs.…”

Section: Introductionmentioning

confidence: 99%

Acromegaly due to a pituitary tumor in a dog – diagnosis, therapy and long-term follow-up

Reusch

Burkhardt

Meier

et al. 2019

SAT

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Acromegaly due to a pituitary tumor has so far only been described in 3 dogs. The present case report describes a 7-year-old male-castrated Labrador Retriever which was referred because of difficultto-control diabetes. Physical examination revealed markedly enlarged head, tongue and paws, widened interdental spaces and thickening of the skin in the head and neck area. IGF-1 and GH were increased and the latter continued to be abnormal after somatostatin application. Computed tomography demonstrated a space-occupying lesion in the pituitary gland and the diagnosis of acromegaly due to a GH-producing tumor of the pituitary was made. The dog underwent radiation therapy with a 6MV linear accelerator (3×8Gy) and improved substantially. Two and a half years after radiation therapy the dog developed lethargy and anorexia and was euthanized. Necropsy was not permitted. This case report represents the description of a dog suffering from pituitary-dependent acromegaly which was successfully treated and had a long-term survival

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“…In the first case, general organomegaly was detected during abdominal ultrasound in addition to pharyngeal stridor, thickened skin, widening of the interdental space and high BCS. Those changes are commonly reported in dogs with acromegaly [21]. Soft-tissue changes may resolve within weeks to months post-treatment but bony changes and widened interdental spaces might persist [21].…”

Section: Discussionmentioning

confidence: 95%

“…Those changes are commonly reported in dogs with acromegaly [21]. Soft-tissue changes may resolve within weeks to months post-treatment but bony changes and widened interdental spaces might persist [21]. The dog may regain a more or less normal appearance [41].…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of diestrus-induced hypersomatotropism and secondary DM is also unclear. A prevalence of 0.15 % (14/9204) of spontaneous hypersomatotropism in entire bitches and 1.7 % (11/656) in entire German Shepherd bitches has been reported [21]. In Sweden, only about 7 % of the bitches are neutered, often late in life due to medical reasons [11] [15].…”

Section: Introductionmentioning

confidence: 99%

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Clinical diabetes mellitus in association with diestrus-induced acromegaly in 2 bitches

Bauer

Hausmann³

et al. 2019

Tierarztl Prax Ausg K

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Two intact bitches aged 9 and 11 years were referred due to chronic polyuria, polydipsia, vomiting, anorexia and progressive lethargy. On clinical examination, signs of tissue overgrowth (large paws, widened interdental space, pharyngeal stridor) were noticed. Diabetes mellitus (DM) was diagnosed in one dog (case 1) and diabetic ketoacidosis (DKA) in the other (case 2). There were increased IGF-1 values suggestive of hypersomatotropism. Progesterone values and pathological findings of the ovaries and uterus indicated diestrus. Diagnosis of diestrus-induced hypersomatotropism was made and ovariohysterectomy was performed in both dogs. Dog 1 also had multiple mammary neoplasms treated with bilateral mastectomy. Treatment resulted in diabetic remission in case 1 and improved glycaemic control in case 2. Overall, diestrus-induced hypersomatotropism is rare but should be considered in any intact diabetic bitch with acromegalic features. Ovariohysterectomy is recommended and associated with a fair to good prognosis.

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Spontaneous acromegaly: A retrospective case control study in German shepherd dogs

Cited by 9 publications

References 35 publications

Urinary excretion of calcium and phosphate in dogs with pituitary‐dependent hypercortisolism: case control study in 499 dogs

Urinary excretion of calcium and phosphate in dogs with pituitary‐dependent hypercortisolism: case control study in 499 dogs

Acromegaly due to a pituitary tumor in a dog – diagnosis, therapy and long-term follow-up

Clinical diabetes mellitus in association with diestrus-induced acromegaly in 2 bitches

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