Spontaneous Acute Subdural Hematoma and Chronic Epidural Hematoma in a Child with F XIII Deficiency

Vural, Murat; Yarar, Çoşkun; Durmaz, Ramazan; Atasoy, Metin Ant

doi:10.1016/j.jemermed.2007.11.041

Cited by 14 publications

(14 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…39 FXIII deficiency was first described in 1960 40 and is another recognized cause of bleeding in children to be mistaken for AHT. 43 As with most inherited disorders, consanguinity increases the risk of FXIII deficiency. 8,39,41,42 Although the majority of affected infants will have umbilical stump bleeding, the absence of this historical finding does not exclude the diagnosis.…”

Section: Factor XIII Deficiencymentioning

confidence: 99%

“…8,39,41,42 Although the majority of affected infants will have umbilical stump bleeding, the absence of this historical finding does not exclude the diagnosis. 43 Since FXIII is integral to clot stability by protecting against dissolution, affected individuals are subject to prolonged and recurrent bleeding from a single event. Although most bleeding in FXIII deficiency involves the skin and soft tissues, the incidence of ICH is higher than that seen in other factor deficiencies.…”

Section: Factor XIII Deficiencymentioning

confidence: 99%

“…43 As with most inherited disorders, consanguinity increases the risk of FXIII deficiency. 43 Although ICH has been described in children and adults with mildly suppressed levels (10-30% FXIII activity), 13,44 it is generally accepted that FXIII deficiency usually becomes clinically apparent with levels of less than 5% activity. 39 ICH is the cause of death in 30% of those who die from hemorrhagic complications of their FXIII deficiency.…”

Section: Factor XIII Deficiencymentioning

confidence: 99%

See 2 more Smart Citations

Conditions Confused with Head Trauma

Greeley¹

2011

Child Abuse and Neglect

View full text Add to dashboard Cite

Section: Factor XIII Deficiencymentioning

confidence: 99%

Section: Factor XIII Deficiencymentioning

confidence: 99%

Section: Factor XIII Deficiencymentioning

confidence: 99%

See 1 more Smart Citation

Conditions Confused with Head Trauma

Greeley¹

2011

Child Abuse and Neglect

View full text Add to dashboard Cite

“…They are frequently due to injury at cerebral bridging veins secondary to head trauma. [ 13 ] ASDHs generally begin to be symptomatic within 72 h and usually occur in young adults.…”

Section: Introductionmentioning

confidence: 99%

Are acute subdural hematomas possible without head trauma?

et al. 2014

View full text Add to dashboard Cite

Acute subdural hematomas (ASDHs) are rarely reported in the literature. In general, it is due to head trauma, but if the traumatic event is very mild, it is inadequate to explain the ASDH occurrence. Risk factors for the development of spontaneous ASDH include hypertension, vascular abnormalities and deficit of coagulation. We present two cases of ASDH in patients with the coagulation deficit and review of the literature to understand the coagulation factors role and platelet role in the management of ASDHs.

show abstract

“…Hemarthrosis occurs in a number of patients,42 with joint-associated bleeding usually occurring periarticular rather than into the joint cavity 7,43. A rare case of subdural and epidural hematoma has also been reported in the literature deeming it necessary to screen a patient with a bleed with no identifiable cause 44. Studies have shown that many patients recover if managed with adequate replacement therapy alone 45.…”

Section: Introductionmentioning

confidence: 99%

New developments in the management of congenital Factor XIII deficiency

Fadoo¹,

Merchant²,

Rehman³

2013

JBM

View full text Add to dashboard Cite

Congenital Factor XIII (FXIII) deficiency is a rare, inherited, autosomal recessive coagulation disorder. Most mutations of this condition are found in the A-subunit with almost half these being missense mutations. Globally, approximately one in three million people suffer from this deficiency. Factor XIII deficiency is associated with severe life threatening bleeding, intracranial hemorrhage, impaired wound healing, and recurrent pregnancy losses. FXIII is known to have a potential role in mediating inflammatory processes, insulin resistance, bone metabolism, neoplasia, and angiogenesis. The algorithm provided for FXIII diagnosis and classification will enable prompt identification and early intervention for controlling potential life threatening complications. Prophylactic replacement therapy using blood products containing FXIII such as fresh frozen plasma, cryoprecipitate, or using FXIII concentrate remains the mainstay for the management of FXIII deficiency. In most parts of the world, cryoprecipitate and plasma transfusions are the only treatments available. Management developments have revealed the effectiveness and safety of recombinant FXIII concentrate for prophylaxis and treatment. The aim of this review is to provide an overview of advancements made in the management of FXIII deficiency from the time it was first detected, highlighting novel developments made in recent years. Greater research is warranted in identifying novel approaches to manage FXIII deficiency in light of its underlying pathophysiology.

show abstract

Spontaneous Acute Subdural Hematoma and Chronic Epidural Hematoma in a Child with F XIII Deficiency

Cited by 14 publications

References 12 publications

Conditions Confused with Head Trauma

Conditions Confused with Head Trauma

Are acute subdural hematomas possible without head trauma?

New developments in the management of congenital Factor XIII deficiency

Contact Info

Product

Resources

About