Spontaneous and Isoprenaline-evoked response of isolated heart preparations from rats submitted to leptin treatment during lactation

Marques, Emiliana Barbosa; Pinto, Lysianne; Nascimento, José; Scaramello, Christianne Brêtas Vieira

doi:10.1016/j.ijcard.2015.05.124

Cited by 3 publications

(1 citation statement)

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“…Toste et al 15 have demonstrated that leptin administration in newborn male Wistar rats during the first 10 of 21 d of lactation leads to several alterations: hyperleptinemia, hyperphagia, overweight, hyperinsulinemia, and hypertriglyceridemia in adulthood, explained by hypothalamic leptin resistance. Besides, Marques et al 16,17 have also characterized diastolic dysfunction in this experimental model in youth that evolved to systolic dysfunction in adulthood along with changes in the spontaneous and sympathetic response of isolated heart preparations compatible to heart failure.…”

Section: Introductionmentioning

confidence: 97%

Leptin administration during lactation leads to different nutritional, biometric, hemodynamic, and cardiac outcomes in prepubertal and adult female Wistar rats

Souza

Pedro

Rocha

et al. 2021

J Dev Orig Health Dis

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Literature reports that insults, such as hormonal disturbances, during critical periods of development may modulate organism physiology and metabolism favoring cardiovascular diseases (CVDs) later in life. Studies show that leptin administration during lactation leads to cardiovascular dysfunction in young and adult male Wistar rats. However, there are sex differences regarding CVD. Thus, the present work aimed to investigate neonatal leptin administration’s consequences on different outcomes in female rats at prepubertal and adult age. Newborn Wistar female rats were divided into two groups, Leptin and Control, receiving daily subcutaneous injections of this adipokine (8 μg/100 g) or saline for the first 10 of 21 d of lactation. Nutritional, biometric, hemodynamic, and echocardiographic parameters, as well as maximal effort ergometer performance, were determined at postnatal days (PND) 30 and 150. Leptin group presented lower food intake (p = 0.0003) and higher feed efficiency (p = 0.0058) between PND 21 and 30. Differences concerning echocardiographic parameters revealed higher left ventricle internal diameter (LVID) in systole (p = 0.0051), as well as lower left ventricle ejection fraction (LVEF) (p = 0.0111) and fractional shortening (FS) (p = 0.0405) for this group at PND 30. Older rats treated with leptin during lactation presented only higher LVID in systole (p = 0.0270). Systolic blood pressure and maximum effort ergometer test performance was similar between groups at both ages. These data suggest that nutritional, biometric, and cardiac outcomes due to neonatal leptin administration in female rats are age-dependent.

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Section: Introductionmentioning

confidence: 97%