Spontaneous and testosterone-induced motility of isolated guinea-pig cauda epididymis

Souza, Maria C. da Silva e; Gimeno, M.F.; Gimeno, A.L.

doi:10.1007/bf01939012

Cited by 15 publications

(6 citation statements)

References 11 publications

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“…On the other hand, indomethacin treatments did not block the stimulatory effect of prostaglandins infused intravenously. This result coincides with observations made in isolated cauda epididymidis from guinea pigs [4]. (0.1 pg/l00 gm) The time taken by spermatozoa in passing through the ductus epididymidis could be related to sperm maturation.…”

Section: Discussionsupporting

confidence: 91%

“…The biological effects of prostaglandins on the smooth muscle of male reproductive tract has not been sufficiently investigated. The effects of prostaglandins on the contractile activity have been studied in isolated organs, e.g., epididymis [4,5], vas deferens [ 1,6,8] and seminal vesicle [8,9]. The epididymis exhibit spontaneous contractility, and at the time of ejaculation a sudden contraction of the cauda epididymidis occurs which could be mediated by stimulation of autonomic nerves [3,71.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Prostaglandins and Indomethacin on Rat Epididymal Responses to Norepinephrine and Acetylcholine

Hib¹,

Oscar²

1978

Archives of Andrology

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a tromethamine salt caused an increase in amplitude and frequency of rat epididymal contractions. Moreover, they caused a significant potentiation of contractile responses of epididymal smooth muscle .to stimulation by norepinephrine or acetylcholine. Indomethacin treatment caused no changes in the spontaneous motility, and this inhibitor of prostaglandins synthesis decreased the responses of epididymis to norepinephrine or acetylcholine. Spontaneous motility of epididymis is possible in the presence of smaller amounts of endogenous prostaglandins, and sudden contraction occurring during ejaculation, induced by sympathetic and parasympathetic nerves stimulation, could be influenced or modulated by prostaglandins.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Effects of Prostaglandins and Indomethacin on Rat Epididymal Responses to Norepinephrine and Acetylcholine

Hib¹,

Oscar²

1978

Archives of Andrology

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“…Contractions of the epididymal duct have been observed and filmed (Muratori, 1953;Risley, 1958), recorded under isometric conditions in large segments of the epididymis (Hib & Caldeyro-Barcia, 1974; de Silva e Souza, Gimeno & Gimeno, 1974) and measured in vivo through an open-ended catheter (Melin, 1970;Knight, 1974;Hib & Ponzio, 1977). These invivo studies have been limited to the epididymal end of the vas deferens and have shown that contractions are local or peristaltic (Muratori, 1953;Risley, 1958) and their frequency declines from the caput towards the vas deferens (Risley, 1963).…”

Section: Introductionmentioning

confidence: 99%

Spontaneous electrical activity of the rat epididymis in vitro

Talo¹,

Jaakkola²,

Markkula-Viitanen³

1979

Reproduction

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Smooth muscle electrical activity was recorded with suction electrodes from the partly or completely uncoiled epididymal duct of the rat in vitro. The electrical activity of the cauda epididymidis consisted of one or few spikes followed by a plateau of 1-2 sec. The frequency of electrical activity declined from the thicker-walled initial segment of the thin-walled initial segment, was increased to the level seen in the initial segment in the thicker, major portion of the caput epididymidis, declined in the corpus and fell steeply in the cauda epididymidis towards the vas deferens. Electrical activity spread over long distances in the distal cauda and epididymal vas. Elsewhere in the epididymis activity remained synchronous only for a short period in short segments.

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“…This activity was reversed to normal by giving testosterone. Martins, Valle & Porto (1940) also report that contractions in the more distal regions of the epididymis are inhibited by male sex hormones, but a stimulatory effect of testosterone on the spontaneous contractility of the isolated guinea-pig cauda epididymidis has been suggested (Da Silva e Souza, Gimeno & Gimeno, 1974). This is surprising because orchidectomy results in a pro¬ gressive decrease of cholinesterase activity (Risley, 1961) and disappearance of adrenergic terminals from the musculature of the cauda epididymidis (Norberg, Risley & Ungerstedt, 1967).…”

mentioning

confidence: 99%

Effect of efferent duct ligation, gonadectomy and testosterone replacement on epididymal contractility in the rat

Hib¹,

Ponzio²

1977

Reproduction

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Spontaneous and testosterone-induced motility of isolated guinea-pig cauda epididymis

Cited by 15 publications

References 11 publications

Effects of Prostaglandins and Indomethacin on Rat Epididymal Responses to Norepinephrine and Acetylcholine

Effects of Prostaglandins and Indomethacin on Rat Epididymal Responses to Norepinephrine and Acetylcholine

Spontaneous electrical activity of the rat epididymis in vitro

Effect of efferent duct ligation, gonadectomy and testosterone replacement on epididymal contractility in the rat

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