Spontaneous Background Pathology in Göttingen Minipigs

Jeppesen, Gitte; Skydsgaard, Mikala

doi:10.1177/0192623314538344

Cited by 38 publications

(140 citation statements)

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“…Inflammatory cell infiltrates were present in Göttingen uteri (Helke et al 2015;Jeppesen and Skydsgaard 2015). No changes were found in the female reproductive tract of Hanfords (Helke et al 2015).…”

Section: Female Reproductive Tractmentioning

confidence: 87%

“…The Yucatans also displayed inflammatory cell infiltrates, hemorrhage, fibrosis, and vacuolation of renal tubular epithelium (Helke et al 2015). Females of all breeds were overrepresented for inflammatory cell infiltration of the kidney, and female Göttingens had increased tubular dilatation and fibrosis compared to males, while Yucatan females had increased tubular degeneration and regeneration compared to males (Helke et al 2015;Jeppesen and Skydsgaard 2015).…”

Section: Urinary Systemmentioning

confidence: 99%

“…Göttingen minipigs displayed many dermal background findings consisting of hyperkeratosis, hyperplasia, exudate, serocellular crust or scab, abscesses or pustules, inflammation, and inflammatory cell infiltrates (Helke et al 2015;Jeppesen and Skydsgaard 2015). Inflammatory cell infiltration was common in Hanfords (Helke et al 2015).…”

Section: Integumentary Systemmentioning

confidence: 99%

“…Yucatans also showed hyperplasia, exudate, and inflammation (Helke et al 2015). Mammary glands of both male and female Göttingens displayed glandular dilatation (Helke et al 2015;Jeppesen and Skydsgaard 2015). Cellular pigmentation of Yucatan mammary glands was present in 2-to 6-month-old females (Helke et al 2015).…”

Section: Integumentary Systemmentioning

confidence: 99%

“…Yucatan males less than 2 months old were found to be immature, and 47% displayed hematopoiesis in the testicle (Helke et al 2015). The epididymis of Göttingens revealed aspermia or oligospermia (Figure 7), luminal cell debris, and epididymal cysts (Figure 8; Helke et al 2015;Jeppesen and Skydsgaard 2015). The epididymides of the Hanford minipigs were immature in 7% of 2-to 6-month-olds (Helke et al 2015).…”

Section: Male Reproductive Tractmentioning

confidence: 99%

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Pigs in Toxicology

et al. 2016

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Both a rodent and a nonrodent species are required for evaluation in nonclinical safety studies conducted to support human clinical trials. Historically, dogs and nonhuman primates have been the nonrodent species of choice. Swine, especially the miniature swine or minipigs, are increasingly being used in preclinical safety as an alternate nonrodent species. The pig is an appropriate option for these toxicology studies based on metabolic pathways utilized in xenobiotic biotransformation. Both similarities and differences exist in phase I and phase II biotransformation pathways between humans and pigs. There are numerous breeds of pigs, yet only a few of these breeds are characterized with regard to both xenobiotic-metabolizing enzymes and background pathology findings. Some specific differences in these enzymes based on breed and sex are known. Although swine have been used extensively in biomedical research, there is also a paucity of information in the current literature detailing the incidence of background lesions and differences between commonly used breeds. Here, the xenobiotic-metabolizing enzymes are compared between humans and pigs, and minipig background pathology changes are reviewed with emphasis on breed differences.

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Section: Female Reproductive Tractmentioning

confidence: 87%

Section: Urinary Systemmentioning

confidence: 99%

Section: Integumentary Systemmentioning

confidence: 99%

Section: Integumentary Systemmentioning

confidence: 99%

Section: Male Reproductive Tractmentioning

confidence: 99%

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Pigs in Toxicology

et al. 2016

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Common Spontaneous and Background Lesions in Laboratory Animals

McInnes¹

2017

Pathology of Taxicologists

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Species Differences in Renal Development and Associated Developmental Nephrotoxicity

Frazier

2017

Birth Defects Research

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The developing kidney is sensitive to both morphological and functional disturbances during the gestational and postnatal phases of growth and differentiation. Exposure to drugs or chemicals during these critical windows of renal development can result in aplasia, dysplasia, polycystic kidney disease, hydronephrosis, or other features characteristic of nephrotoxicity, including tubule dilation, necrosis, or mineralization. Functional effects can occur without associated morphological abnormalities. Differences in the timing of nephrogenesis and morphologic renal development among species help to explain specific phenotypes of various gestational and postnatal teratogens and nephrotoxins. Functional maturation follows anatomical maturation, but important differences in maximally achieved glomerular filtration rate, concentrating ability and acid-base equilibrium between species makes comparison of these timings critical for accurate and consistent translation of laboratory animal toxicity data to the human clinical experience. Species and age dependent differences in the maturation of kidney transporters, renal xenobiotic metabolism and renal blood flow can have a profound effect on the toxicity profiles of agents and marked differences in the tolerability based on age. Advances in the understanding of the genetics of inherited renal diseases and the underlying cellular and molecular pathogenesis of renal developmental anomalies has helped provide mechanistic understanding of many teratogenic and perinatal nephrotoxic agents. Investigative studies have provided important translational and mechanistic information for assessing human pediatric nephrotoxic potential. Birth Defects Research 109:1243-1256, 2017. © 2017 Wiley Periodicals, Inc.

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Spontaneous Background Pathology in Göttingen Minipigs

Cited by 38 publications

References 4 publications

Pigs in Toxicology

Pigs in Toxicology

Common Spontaneous and Background Lesions in Laboratory Animals

Species Differences in Renal Development and Associated Developmental Nephrotoxicity

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