Spontaneous Carcinoma of the Glandular Stomach in Rattus (Mastomys) Natalensis, an African Rodent

Oettlé, A. G.

doi:10.1038/bjc.1957.50

Cited by 56 publications

(23 citation statements)

References 7 publications

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“…animals were reported to develop stomach cancer frequently (Oettle, 1957). Thus they were extensively investigated for various spontaneous tumours as potential animal models in oncology, especially in stomach cancer (Snell & Stewart, 1965, 1967, 1969aSnell, 1969;Hollander & Higginson, 1971;Fujii & Sato, 1972;Soga & Sato, 1978).…”

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confidence: 99%

Adrenocortical zonation of inbred wild-coloured mastomys, Praomys coucha: a new border zone in the cortex of females

et al. 1990

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SummaryAdrenal glands were examined in the inbred strain of wild-coloured mastomys (Praomys coucha), MWC. The most characteristic findings were emergence of a border zone between the zona fasciculata and z. reticularis of the cortex in females but not in males, and persistence of broad z. reticularis in males. The border zone was typically comprised of vacuolated cell layers, nodular layers and fibrous tissue. Vacuolated cells increased in number during pregnancy and partially disappeared during lactation. Growth of the nodules was greatly enhanced in both number and size during lactation. Thus, multiparae had very thick border zones composed predominantly of large nodules and, additionally, of vacuolated cells and fibrous tissue. The z. reticularis was compressed into a cord of closely packed cells by the expanded border zone in multiparous females but it continued to thicken with age in males. These changes produced completely different cortical zonation in the adrenal between sexes.

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Adrenocortical zonation of inbred wild-coloured mastomys, Praomys coucha: a new border zone in the cortex of females

et al. 1990

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“…Praomys (Mastomys) natalensis is an African rodent with a high incidence of spontaneous stomach tumours [5]. A Z strain of this species has been reported to develop carcinoids along the greater curvature of the body as well as adenocarcinoma along the lesser curvature of the antrum, the predilection site of human gastric adenocarcinoma [6].…”

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The effect of colonisation by Helicobacter pylori in Praomys (Mastomys) natalensis on the incidence of carcinoids

Koga¹,

Takahashi²,

Satô³

et al. 2002

Journal of Medical Microbiology

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An animal model of experimental gastric Helicobacter pylori infection has been developed in the Z strain of Praomys (Mastomys) natalensis; this animal has been reported to develop gastric carcinoids and adenocarcinoma spontaneously. In the present study, male and female Mastomys were killed at 1, 2, 4, 8 and 16 weeks after H. pylori inoculation. Colonisation of H. pylori was maintained in the stomachs of all animals for up to 16 weeks. H. pylori were mainly found in the antrum. Lymphoid infiltration appeared in the antral lamina propria and submucosa in all male and female animals from 4 to 16 weeks after inoculation. On microscopic examination after immunostaining for H. pylori, the organisms were detected in the antral mucus layer of the gastric epithelium. Serum immunoglobulin G specific for H. pylori could be detected 2 weeks after inoculation in female and 4 weeks after inoculation in male Mastomys, and persisted throughout the 16-week study period. At 18 months after inoculation, H. pylori positive rates for male and female Mastomys were 15 of 21 and 7 of 27, respectively. Carcinoids developed in 27 of 100 inoculated and in 49 of 100 uninoculated male, and in 5 of 100 inoculated and in 21 of 100 uninoculated female animals at 18 months after inoculation. Adenocarcinoma developed in 1 of 100 male Mastomys in both the inoculated and uninoculated groups, but in none of the female animals in either the inoculated or uninoculated groups. These results indicate that antrum-predominant colonisation by H. pylori caused the decrease in incidence of carcinoid formation in Mastomys.

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“…It is important to know the characteristics of preimplantation development mediate in size between the mouse and rat. This species provides a good model for cancer research because it develops a wide variety of neoplastic lesions [1]. Mastomys has also received attention as a new laboratory rodent with great phenotypic variations found in many organs [2][3][4].…”

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Preimplantation Embryo Development in Mastomys (Praomys coucha) In Vivo and In Vitro.

Ogura

Matsuda

Mochida

et al. 1997

Journal of Reproduction and Development

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Abstract. Mastomys (Praomys coucha) is a small murine rodent native in Africa. The present study was undertaken to investigate the developmental time course of mastomys embryos in vivo and the rate of development in vitro. Mastomys embryos developing in vivo exhibited a long 2-cell stage, which lasted from late Day 1 through Day 3. At Day 4, most embryos developed to the 8-cell or morula stages and at Day 5, all embryos reached the blastocyst stage. The attachment of embryos to the endometrium began at Day 5, as revealed by histological examinations. The development in vitro was investigated in different media with three inbred strains and an F1 hybrid. When 1-cell embryos from inbred mastomys were cultured in Whitten's medium (WM), none of them (n=61) developed beyond the 2-cell stage. Embryos of the same strains collected at Day 2 (2-cells) reached the blastocyst stage (46%, 31/67) in the same medium. Meanwhile, 1-cell embryos from F1 hybrid mastomys developed to the blastocyst stage in WM (13%, 13/71), indicating the presence of a strong heterosis effect. CZB medium, which lacks glucose and contains glutamine and EDTA, supported the development of 1-cell inbred embryos to the blastocyst stage (24%, 17/70). Supplementation of glutamine, but not EDTA, to WM stimulated the development of 1-cells to the blastocyst stage (22%, 11/51). These findings indicate that the development of mastomys embryos in vitro is both strain and medium dependent and that glutamine may play a crucial role in early development of mastomys embryos.

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Spontaneous Carcinoma of the Glandular Stomach in Rattus (Mastomys) Natalensis, an African Rodent

Abstract: Images Figs. 18-21 Figs. 11-13 Figs. 14-17 Figs. 6-10 Figs. 1-5

Cited by 56 publications

References 7 publications

Adrenocortical zonation of inbred wild-coloured mastomys, Praomys coucha: a new border zone in the cortex of females

Adrenocortical zonation of inbred wild-coloured mastomys, Praomys coucha: a new border zone in the cortex of females

The effect of colonisation by Helicobacter pylori in Praomys (Mastomys) natalensis on the incidence of carcinoids

Preimplantation Embryo Development in Mastomys (Praomys coucha) In Vivo and In Vitro.

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