Spontaneous Clearance of Hepatitis C Genotype 4 After Liver Retransplantation

Elsiesy, Hussien; Abaalkhail, Faisal; Sebayel, Mohammed Al; Broering, Dieter; Hamoudi, Waleed Al; Yousif, Sarra; Al-Kattan, Wael; Selim, Khaled

doi:10.1016/j.transproceed.2014.10.065

Cited by 5 publications

(11 citation statements)

References 19 publications

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“…This review revealed a small number of patients ( n = 8, including our four cases) in four reports, including the present case report [ 2 , 6 , 7 ] (Table 2 ). The population included six men and two women aged 32–66 years.…”

Section: Case Presentationmentioning

confidence: 87%

“…Hepatitis C virus (HCV) infection-associated end-stage liver disease is the leading indication for liver transplantation (LT). HCV recurrence in the liver graft is common when HCV viremia is confirmed during LT, leading to an accelerated rate of graft failure [ 1 , 2 ]. In the liver transplant setting, immunosuppression is an important determinant for increased HCV replication.…”

Section: Introductionmentioning

confidence: 99%

“…Spontaneous HCV clearance in chronic carriers of the virus was reportedly consistent in a small post-LT patient population, although the natural course of HCV has not been completely elucidated [ 4 , 5 ]. Furthermore, spontaneous HCV clearance after LT is rare and few cases have been reported [ 2 ]. Here, we report the clinical features of four patients, of whom three patients presented a spontaneous HCV clearance over a short duration after LT (case 1, case 2, and case 3) and one presented transient viral disappearance postoperatively (case 4).…”

Section: Introductionmentioning

confidence: 99%

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Spontaneous clearance of hepatitis C virus after liver transplantation: a report of four cases

et al. 2015

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End-stage liver disease associated with hepatitis C virus (HCV) infection is the leading indication for liver transplantation. Hepatitis C virus infection recurrence in the graft is common under immunosuppression, leading to an accelerated rate of graft failure. We report the clinical features of four of our patients: three patients presenting with spontaneous hepatitis C virus clearance after liver transplantation and one presenting with transient disappearance of hepatitis C virus postoperatively. The transitional period from surgery to hepatitis C virus clearance was <5 months for all patients. The immunosuppression therapy included tacrolimus, mycophenolate mofetil, and corticosteroids. One ABO-incompatible patient presented spontaneous viral clearance postoperatively for the last 5 years. Two patients had episodes of severe bacterial infection, which resulted in a temporary reduction of immunosuppression. Two patients presented with a transient elevation of transaminase preceding spontaneous hepatitis C virus clearance. These clinical findings suggested that factors including surgical stress, severe bacterial infection, and temporary interruption of immunosuppression were correlated with the reactivation of nonspecific immune responses in the hosts, resulting in spontaneous hepatitis C virus clearance postoperatively.

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Section: Case Presentationmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Spontaneous clearance of hepatitis C virus after liver transplantation: a report of four cases

et al. 2015

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“…Spontaneous clearance of HCV is rare in the immunocompromised patients post liver transplantation. There are only few case reports about spontaneous clearance of HCV after liver and renal transplantation particularly after withdrawal of immunosuppressive agents [8,[11][12][13][14]. Here we report on the clinical features of two patients with spontaneous clearance after liver transplantation.…”

mentioning

confidence: 90%

“…There are several reports of spontaneous HCV clearance after liver transplantation [8,[11][12][13][23][24][25][26][27][28]. Different reports had identified different speculative factors for viral clearance; withdrawal of immunosuppression [8,24], renal impairment, proteinuria, pretransplant exposure to interferon, and change of immunosuppression, antiretroviral therapy given for HIV coinfection or HBV coinfection [23], liver transplantation from homozygous IL28B CC donors [11].…”

Section: Introductionmentioning

confidence: 99%

Spontaneous Clearance of Hepatitis C Virus after Liver Transplantation, A Report of Two Cases

Elsiesy¹

2017

GHOA

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Background: End-stage liver cirrhosis due to HCV is the main indication for liver transplantation worldwide. Recurrence and rapid replication of HCV after liver transplantation is universal and leads to decreased graft and patient survival. Among patients exposed to HCV, spontaneous clearance of the virus is rare. Here we report two patients with spontaneous clearance after liver transplantation.Case Reports: We report two female patients, with HCV cirrhosis, received liver transplantation (one DDLT and one LDLT), they cleared HCV on average of 20 days post liver transplant, one remained negative throughout while the other patient showed relapse on re-testing 2 years later.

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Graft-versus-host disease following liver transplantation: A systematic review of literature

Kneifel,

Vogel,

Bormann

et al. 2023

Hepatology Communications

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Background: Graft-versus-host disease following liver transplantation is a serious and usually fatal complication. Data identifying the risk factors and specifying the diagnosis and treatment options of the disease are scarce and contentious. Moreover, recommendations for therapeutic approaches are similarly sparse. Methods: A systematic review of the literature from 1988 to 2020 on graft-versus-host disease following liver transplantation was performed using the PubMed and MEDLINE databases. Medical subject headings, such as graft-versus-host disease and GvHD were used in combination with solid organ transplant, transplantation, or liver transplant. Following duplicate removal, 9298 articles were screened for suitability. A total of 238 full-text articles were analyzed for eligibility, resulting in 130 eligible articles for meta-analysis. Two hundred twenty-five patients developing graft-versus-host disease following liver transplantation reported herein were mainly published in case reports and case series. Results: Graft-versus-host disease occurred with an incidence of 1.2%. 85% developed following deceased donor liver transplant and 15% following living-related donor liver transplantation. The median follow-up period following liver transplantation was 84 days (interquartile range, 45–180). The median time from liver transplantation to graft-versus-host disease onset was 30 days (interquartile range, 21–42). The main clinical features included skin rash (59%), fever (43%), diarrhea (36%), and pancytopenia (30%). The overall mortality rate was 71%. Neither univariate (HR = 0.999; 95% CI, 0.493–2.023; p = 1.0) nor multivariate Cox regression analysis revealed a significant correlation between adaptation of immunosuppression and survival probability (HR = 1.475; 95% CI, 0.659–3.303; p = 0.3). Conclusions: This systematic review suggests that an increase in immunosuppressive regimen does not yield any survival benefit in patients suffering from graft-versus-host disease following liver transplantation.

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Spontaneous Clearance of Hepatitis C Genotype 4 After Liver Retransplantation

Cited by 5 publications

References 19 publications

Spontaneous clearance of hepatitis C virus after liver transplantation: a report of four cases

Spontaneous clearance of hepatitis C virus after liver transplantation: a report of four cases

Spontaneous Clearance of Hepatitis C Virus after Liver Transplantation, A Report of Two Cases

Graft-versus-host disease following liver transplantation: A systematic review of literature

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