Spontaneous clearance of the human papilloma virus as a result of suppressive therapy with acyclic nucleosides of a recurrent herpes-viral infection

Tapilskaya, Tapilskaya N.I.; Тапильская, Н. И.; Воробцова, И Н; Glushakov, Ruslan I.

doi:10.26442/2079-5696_19.3.55-61

GYN

2017

DOI: 10.26442/2079-5696_19.3.55-61

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Spontaneous clearance of the human papilloma virus as a result of suppressive therapy with acyclic nucleosides of a recurrent herpes-viral infection

Tapilskaya N.I. Tapilskaya

Н. И. Тапильская²,

И Н Воробцова

et al.

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The role of papillomavirus and herpesvirus infections in the origins and genesis of genital endometriosis. A literature review

Khanova,

Khachaturian,

Khusnutdinova

et al. 2023

Journal of obstetrics and women's diseases

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Endometriosis is a chronic multifactorial disease that affects one in ten women of reproductive age. Genetic, endocrine and immunological factors play an important role in the pathogenesis of endometriosis. In recent years, an increasing number of studies have been devoted to the role of vaginal microbiota in the pathogenesis of endometriosis. However, the role of viral infections, such as papillomavirus and herpesvirus infections, in the development of the disease has not been sufficiently studied. The review highlights current ideas about the role of human papillomavirus and herpesvirus infections in the genesis of endometriosis. The data obtained have convinced us of the need to further search for new relationships between papillomavirus and herpesvirus infections, microbiota of reproductive organs and pathogenesis of such a complicated disease as endometriosis.

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The role of papillomavirus and herpesvirus infections in the origins and genesis of genital endometriosis. A literature review

Khanova,

Khachaturian,

Khusnutdinova

et al. 2023

Journal of obstetrics and women's diseases

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Virus-associated chronic endometritis: treatment options

et al. 2022

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Aim. To evaluate the effectiveness of Alloferon (Allokin-alfa) in the complex treatment of virus-associated chronic endometritis (CE) in patients with infertility, papillomavirus infection (PVI) persisting in the uterine cavity, and recurrent herpes-virus infection localized in the genital area. Materials and methods. A prospective (n=33) open randomized (2:1) study was conducted to assess the efficacy of Alloferon (Allokin-alfa) in the complex treatment of CE in patients with infertility, PVI, and recurrent herpes-virus infection, aged 25 to 37 years (median age 31 [29; 32.5] years). All patients received valacyclovir therapy at 500 mg once daily for 30 days from the day of randomization. Patients in the main group (n=21) simultaneously with the start of antiviral therapy received Allokin-alfa as 9 subcutaneous injections once every two days (one injection every other day). The uterine cavity microbiota of the patients was assessed 3 months after treatment, and histological and immunohistochemical studies of endometrial biopsy specimens were performed. Results. The microbiological data analysis showed HPV elimination in 71.4% vs 16.7% of patients in the alloferon and control groups, respectively (2 7.102, p=0.008). Also, in the main group, a significant decrease in the severity of CE (2 27.586, p0.001) and p16ink4a protein expression levels (2 6.17, p=0.013) were observed. Conclusion. In the treatment of virus-associated CE, the addition of alloferon to virus-suppressive therapy leads to higher rates of HPV elimination from the uterine cavity and significantly reduces the severity of CE.

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Spontaneous clearance of the human papilloma virus as a result of suppressive therapy with acyclic nucleosides of a recurrent herpes-viral infection

Cited by 2 publications

References 0 publications

The role of papillomavirus and herpesvirus infections in the origins and genesis of genital endometriosis. A literature review

The role of papillomavirus and herpesvirus infections in the origins and genesis of genital endometriosis. A literature review

Virus-associated chronic endometritis: treatment options

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