Spontaneous closure of traumatic macular hole in a pediatric patient

Pascual-Camps, Isabel; Barranco-González, H.; Dolz-Marco, Rosa; Gallego-Pinazo, Roberto

doi:10.1016/j.jaapos.2017.04.009

Cited by 9 publications

(2 citation statements)

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“…Unlike in idiopathic macular holes (IMH), spontaneous closure is common in TMH. In the literature, the spontaneous closure rates vary between 10 and 50% [7,[12][13][14][15][16][17][18][19][20]. Functional prognosis is often limited due to accompanying trauma-induced retinal pathologies, respectively.…”

Section: Introductionmentioning

confidence: 99%

Cell composition at the vitreomacular interface in traumatic macular holes

Guenther

Schumann²,

Zaytseva

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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Purpose To describe characteristics of the vitreomacular interface (VMI) in traumatic macular holes (TMH) compared to idiopathic macular holes (IMH) using immunofluorescence and electron microscopy, and to correlate with clinical data. Methods For immunocytochemical and ultrastructural analyses, premacular tissue with internal limiting membrane (ILM) and epiretinal membrane (ERM) was harvested during vitrectomy from 5 eyes with TMH and 5 eyes with IMH. All specimens were processed as flat mounts for phase-contrast microscopy, interference and fluorescence microscopy, and transmission electron microscopy (TEM). Primary antibodies were used against microglial and macroglial cells. Clinical data was retrospectively evaluated. Results Surgically excised premacular tissue of eyes with TMH showed a less pronounced positive immunoreactivity for anti-glutamine synthetase, anti-vimentin and anti-IBA1 compared to eyes with IMH. Cell nuclei staining of the flat-mounted specimens as well as TEM presented a lower cell count in eyes with TMH compared to IMH. All detected cells were found on the vitreal side of the ILM. No collagen fibrils were seen in specimens of TMH. According to patients’ age, intraoperative data as well as spectral-domain optical coherence tomography (SD-OCT) analysis revealed an attached posterior vitreous in the majority of TMH cases (60%), whereas all eyes with IMH presented posterior vitreous detachment. Conclusion The vitreomacular interface in TMH and IMH shows significant differences. In TMH, glial cells are a rare finding on the vitreal side of the ILM.

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Section: Introductionmentioning

confidence: 99%

Cell composition at the vitreomacular interface in traumatic macular holes

Guenther

Schumann²,

Zaytseva

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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“…Treatment includes observation, as spontaneous closure has been reported [11–15], as well as surgical closure with vitrectomy if necessary.…”

Section: Introductionmentioning

confidence: 99%

Traumatic Macular Hole: Diagnosis, Natural History, and Management

Budoff

Bhagat

Zarbin

2019

Journal of Ophthalmology

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Traumatic macular hole occurs most often in young men and can present after various types of injuries. Traumatic macular holes result from anteroposterior and tangential vitreoretinal traction and may exhibit concurrent additional pathologies such as Berlin’s edema and subretinal fluid. Optical coherence tomography can play an essential role in patient management both at presentation and during follow-up. Initial management consists of observation, but macular hole repair can be performed if spontaneous resolution does not occur. Upon macular hole closure, vision may improve, on average, by two lines or more but may be limited by associated macular pathology.

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