Spontaneous coronary artery dissection in ergotamine abuse

Acute coronary syndrome with elevation of ST associated with ergotamine abuse

“…The acute coronary syndrome associated a spontaneous coronary dissection (SCD) has been reported in association with connective tissue disorders (like lupus erythematosous, Marfan's syndrome and Ehlers-Danlos syndrome) or described in the third trimester of pregnancy or the postpartum period. SCD can be associated with use of several drugs as cocaine [2]. These clinical situations were excluded in our patient.…”

“…The vasoconstriction generated by ergotamine can induce acute increases in parietal stress of the artery with an increased risk of dissection, even in those with normal coronary arteries [2][3].…”

Headache, Cerebral Aneurysms, and the Use of Triptans and Ergot Derivatives

“…Despite these theoretical concerns, there is little evidence to support them. There are isolated case reports questioning an association between chronic ergotamine abuse and bilateral external iliac artery dissection, coronary artery dissections (one with cabergoline), spontaneous dissection of cervico‐cephalic, renal and hepatic arteries and of the descending aorta, and carotid artery dissection . However, an association between these cases of ergotamine abuse and arterial dissections cannot be clearly made.…”